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Obesity enriches for tumor protective microbial metabolites and treatment refractory cells to confer therapy resistance in PDAC.

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第一作者： Kousik,Kesh

第一单位： Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA.;Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL, USA.

作者： Kousik,Kesh ^[1] ; Roberto,Mendez ^[1] ; Beatriz,Mateo-Victoriano ^[2] ; Vanessa T,Garrido ^[1] ; Brittany,Durden ^[2] ; Vineet K,Gupta ^[1] ; Alfredo,Oliveras Reyes ^[2] ; Nipun,Merchant ^[1] ; Jashodeep,Datta ^[1] ; Santanu,Banerjee ^[3] ; Sulagna,Banerjee ^[1]

作者单位： Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA.;Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL, USA. ^[1] Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA. ^[2] Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA.;Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL, USA.;Miami Integrative Metabolomics Research Center, University of Miami, Miami, FL, USA. ^[3]

关键词 Pancreatic cancer chemoresistance gut microbiome obesity queuosine S-adenosyl methionine

医学主题词动物(Animals);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);核苷Q(Nucleoside Q);肥胖症(Obesity);胰腺肿瘤(Pancreatic Neoplasms)

DOI 10.1080/19490976.2022.2096328

PMID 35816618

发布时间 2024-01-02

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