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Surface cholesterol-enriched domains specifically promote invasion of breast cancer cell lines by controlling invadopodia and extracellular matrix degradation.

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第一作者： Mauriane,Maja

第一单位： CELL Unit and PICT Imaging Platform, de Duve Institute, UCLouvain, B1.75.05, avenue Hippocrate, 75, 1200, Brussels, Belgium.

作者： Mauriane,Maja ^[1] ; Danahe,Mohammed ^[2] ; Andra C,Dumitru ^[2] ; Sandrine,Verstraeten ^[3] ; Maxime,Lingurski ^[1] ; Marie-Paule,Mingeot-Leclercq ^[3] ; David,Alsteens ^[2] ; Donatienne,Tyteca ^[4]

作者单位： CELL Unit and PICT Imaging Platform, de Duve Institute, UCLouvain, B1.75.05, avenue Hippocrate, 75, 1200, Brussels, Belgium. ^[1] Louvain Institute of Biomolecular Science and Technology (LIBST), UCLouvain, Ottignies-Louvain-la-Neuve, Belgium. ^[2] Cellular and Molecular Pharmacology Unit (FACM), Louvain Drug Research Institute, UCLouvain, Brussels, Belgium. ^[3] CELL Unit and PICT Imaging Platform, de Duve Institute, UCLouvain, B1.75.05, avenue Hippocrate, 75, 1200, Brussels, Belgium. donatienne.tyteca@uclouvain.be. ^[4]

关键词 Cholesterol transversal asymmetry Endocytosis MCF10A series MDA-MB-231 Matrigel invasion Membrane contact sites

医学主题词乳腺肿瘤(Breast Neoplasms);胆固醇(Cholesterol);细胞外基质(Extracellular Matrix);女(雌)性(Female);人类(Humans);肿瘤侵润(Neoplasm Invasiveness)

DOI 10.1007/s00018-022-04426-8

PMID 35819726

发布时间 2022-10-05

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