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Cell-free production of personalized therapeutic phages targeting multidrug-resistant bacteria.

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第一作者： Quirin,Emslander

第一单位： Institute of Virology, TUM School of Medicine, Technical University of Munich, 81675 Munich, Germany.

作者： Quirin,Emslander ^[1] ; Kilian,Vogele ^[2] ; Peter,Braun ^[3] ; Jana,Stender ^[3] ; Christian,Willy ^[4] ; Markus,Joppich ^[5] ; Jens A,Hammerl ^[6] ; Miriam,Abele ^[7] ; Chen,Meng ^[7] ; Andreas,Pichlmair ^[1] ; Christina,Ludwig ^[7] ; Joachim J,Bugert ^[3] ; Friedrich C,Simmel ^[2] ; Gil G,Westmeyer ^[8]

作者单位： Institute of Virology, TUM School of Medicine, Technical University of Munich, 81675 Munich, Germany. ^[1] Department of Physics, Technical University of Munich, 85748 Garching, Germany. ^[2] Bundeswehr Institute of Microbiology, 80937 Munich, Germany. ^[3] Bundeswehrkrankenhaus Berlin, 10115 Berlin, Germany. ^[4] Department of Informatics, Ludwigs-Maximilian-Universität München, Amalienstraße 17, 80333 Munich, Germany. ^[5] Department of Biological Safety, German Federal Institute for Risk Assessment, Max-Dohrn Str. 8-10, D-10589 Berlin, Germany. ^[6] BayBioMS, Bavarian Center for Biomolecular Mass Spectrometry, Technical University of Munich, 85354 Freising, Germany. ^[7] Department of Chemistry & TUM School of Medicine, Technical University of Munich, 85748 Garching, Germany; Institute for Synthetic Biomedicine, Helmholtz Zentrum München, 85764 Oberschleißheim, Germany. Electronic address: gil.westmeyer@tum.de. ^[8]

关键词 biosafety cell-free production multidrug-resistant bacteria non-genomic phage engineering non-structural phage proteins personalized medicine phage therapy therapeutic bacteriophages time-resolved proteomics

医学主题词细菌(Bacteria);细菌噬菌体(Bacteriophages);抗药性, 多种, 细菌(Drug Resistance, Multiple, Bacterial);大肠杆菌(Escherichia coli);肺炎克雷伯菌(Klebsiella pneumoniae);蛋白质组学(Proteomics)

DOI 10.1016/j.chembiol.2022.06.003

PMID 35820417

发布时间 2022-10-13

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