Synthesis and in vitro proof-of-concept studies on bispecific iron oxide magnetic nanoparticles targeting PSMA and GRP receptors for PET/MR imaging of prostate cancer.

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作者： Christos,Liolios ^[1] ; Theodora S,Koutsikou ^[2] ; Evangelia-Alexandra,Salvanou ^[3] ; Fotis,Kapiris ^[3] ; Evangelos,Machairas ^[4] ; Marianna,Stampolaki ^[4] ; Antonios,Kolocouris ^[4] ; Eleni Κ,Efthimiadou ^[5] ; Penelope,Bouziotis ^[6]

作者单位： Radiochemical Studies Laboratory, Institute of Nuclear & Radiological Sciences & Technology, Energy & Safety (INRASTES), National Centre for Scientific Research (NCSR) "Demokritos", Athens 15341, Greece; Laboratory of Medicinal Chemistry, Section of Pharmaceutical Chemistry, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis - Zografou, Athens 15771, Greece. Electronic address: liolios.xr@gmail.com. ^[1] Radiochemical Studies Laboratory, Institute of Nuclear & Radiological Sciences & Technology, Energy & Safety (INRASTES), National Centre for Scientific Research (NCSR) "Demokritos", Athens 15341, Greece; Laboratory of Inorganic Chemistry, Section of Ιnorganic Chemistry - Inorganic Chemical Technology - Environmental Chemistry, Department of Chemistry, National and Kapodistrian University of Athens Panepistimiopolis - Zografou, Athens 15771, Greece. ^[2] Radiochemical Studies Laboratory, Institute of Nuclear & Radiological Sciences & Technology, Energy & Safety (INRASTES), National Centre for Scientific Research (NCSR) "Demokritos", Athens 15341, Greece. ^[3] Laboratory of Medicinal Chemistry, Section of Pharmaceutical Chemistry, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis - Zografou, Athens 15771, Greece. ^[4] Laboratory of Inorganic Chemistry, Section of Ιnorganic Chemistry - Inorganic Chemical Technology - Environmental Chemistry, Department of Chemistry, National and Kapodistrian University of Athens Panepistimiopolis - Zografou, Athens 15771, Greece. ^[5] Radiochemical Studies Laboratory, Institute of Nuclear & Radiological Sciences & Technology, Energy & Safety (INRASTES), National Centre for Scientific Research (NCSR) "Demokritos", Athens 15341, Greece. Electronic address: bouzioti@rrp.demokritos.gr. ^[6]

关键词 (68)Ga Gastrin releasing peptide receptor (GRPR)Iron oxide magnetic nanoparticles PET/MRI Prostate cancer Prostate specific membrane antigen (PSMA)