Stochastic models of nucleosome dynamics reveal regulatory rules of stimulus-induced epigenome remodeling.

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作者： Jinsu,Kim ^[1] ; Katherine M,Sheu ^[2] ; Quen J,Cheng ^[3] ; Alexander,Hoffmann ^[4] ; German,Enciso ^[5]

作者单位： Department of Mathematics, Pohang University of Science and Technology, Pohang, South Korea. ^[1] Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, USA; Institute for Quantitative and Computational Biosciences, University of California, Los Angeles, Los Angeles, CA, USA. ^[2] Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, USA; Department of Medicine, Division of Infectious Diseases, University of California, Los Angeles, Los Angeles, CA, USA. ^[3] Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, USA; Institute for Quantitative and Computational Biosciences, University of California, Los Angeles, Los Angeles, CA, USA. Electronic address: ahoffmann@ucla.edu. ^[4] Department of Mathematics, University of California, Irvine, Irvine, CA, USA; Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA, USA. Electronic address: enciso@uci.edu. ^[5]

关键词 ATAC-seq CP: Molecular biology NF-κB cooperativity histone eviction nucleosome dynamics random walk signal-dependent transcription factor stochastic model time-dependent Markov model

主题词染色质组装和分解(Chromatin Assembly and Disassembly);DNA(DNA);核小体(Nucleosomes);转录因子(Transcription Factors)

DOI 10.1016/j.celrep.2022.111076

PMID 35830792

发布时间 2024-09-16

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