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Discovery of carbamate-based N-salicyloyl tryptamine derivatives as novel pleiotropic agents for the treatment of Alzheimer's disease.

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第一作者： Yuying,Wang

第一单位： State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China.

作者： Yuying,Wang ^[1] ; Honghua,Zhang ^[2] ; Dan,Liu ^[2] ; Xuelin,Li ^[3] ; Lin,Long ^[3] ; Ying,Peng ^[3] ; Fujian,Qi ^[4] ; Yuqing,Wang ^[2] ; Weifan,Jiang ^[5] ; Zhen,Wang ^[6]

作者单位： State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China. ^[1] School of Pharmacy, Lanzhou University, Lanzhou 730000, China. ^[2] School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China. ^[3] Gansu Key Laboratory of Biomonitoring and Bioremediation for Environmental Pollution, School of Life Sciences, Lanzhou University, Lanzhou 730000, China. ^[4] School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China. Electronic address: jiangwf@usc.edu.cn. ^[5] State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China; School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China; School of Pharmacy, Lanzhou University, Lanzhou 730000, China. Electronic address: zhenw@lzu.edu.cn. ^[6]

关键词 Alzheimer’s disease Anti- neuroinflammation Anti-oxidation Butyrylcholinesterase inhibitor Carbamate Multi-target-directed ligands Neuroprotective effect