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Genetic regulation of OAS1 nonsense-mediated decay underlies association with COVID-19 hospitalization in patients of European and African ancestries.

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作者: A Rouf,Banday [1] ; Megan L,Stanifer [2] ; Oscar,Florez-Vargas [1] ; Olusegun O,Onabajo [1] ; Brenen W,Papenberg [1] ; Muhammad A,Zahoor [3] ; Lisa,Mirabello [4] ; Timothy J,Ring [1] ; Chia-Han,Lee [1] ; Paul S,Albert [5] ; Evangelos,Andreakos [6] ; Evgeny,Arons [7] ; Greg,Barsh [8] ; Leslie G,Biesecker [9] ; David L,Boyle [10] ; Mark S,Brahier [11] ; Andrea,Burnett-Hartman [12] ; Mary,Carrington [13] ; Euijin,Chang [14] ; Pyoeng Gyun,Choe [14] ; Rex L,Chisholm [15] ; Leandro M,Colli [16] ; Clifton L,Dalgard [17] ; Carolynn M,Dude [18] ; Jeff,Edberg [19] ; Nathan,Erdmann [20] ; Heather S,Feigelson [12] ; Benedito A,Fonseca [21] ; Gary S,Firestein [10] ; Adam J,Gehring [22] ; Cuncai,Guo [23] ; Michelle,Ho [1] ; Steven,Holland [24] ; Amy A,Hutchinson [25] ; Hogune,Im [26] ; Les'Shon,Irby [18] ; Michael G,Ison [27] ; Naima T,Joseph [28] ; Hong Bin,Kim [29] ; Robert J,Kreitman [7] ; Bruce R,Korf [30] ; Steven M,Lipkin [31] ; Siham M,Mahgoub [32] ; Iman,Mohammed [33] ; Guilherme L,Paschoalini [16] ; Jennifer A,Pacheco [15] ; Michael J,Peluso [34] ; Daniel J,Rader [35] ; David T,Redden [36] ; Marylyn D,Ritchie [35] ; Brooke,Rosenblum [9] ; M Elizabeth,Ross [33] ; Hanaisa P Sant,Anna [37] ; Sharon A,Savage [4] ; Sudha,Sharma [38] ; Eleni,Siouti [6] ; Alicia K,Smith [18] ; Vasiliki,Triantafyllia [6] ; Joselin M,Vargas [1] ; Jose D,Vargas [39] ; Anurag,Verma [35] ; Vibha,Vij [40] ; Duane R,Wesemann [41] ; Meredith,Yeager [25] ; Xu,Yu [42] ; Yu,Zhang [24] ; Steeve,Boulant [43] ; Stephen J,Chanock [37] ; Jordan J,Feld [22] ; Ludmila,Prokunina-Olsson [44]
作者单位: Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA. [1] Department of Infectious Diseases, Molecular Virology, University Hospital Heidelberg, Heidelberg, Germany.;Department of Molecular Genetics and Microbiology, College of Medicine, University of Florida, Gainesville, FL, USA. [2] Toronto Centre for Liver Disease, Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada. [3] Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA. [4] Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA. [5] Laboratory of Immunobiology, Center for Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece. [6] Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA. [7] HudsonAlpha Institute for Biotechnology, Huntsville, AL, USA. [8] Center for Precision Health Research, National Human Genome Research Institute, Bethesda, MD, USA. [9] Altman Clinical & Translational Research Institute, UC San Diego Health Sciences, San Diego, CA, USA. [10] Georgetown University School of Medicine, Washington, DC, USA. [11] Institute for Health Research, Kaiser Permanente Colorado, Aurora, CO, USA. [12] Basic Science Program, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, MD, USA.;Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.;Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA. [13] Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea. [14] Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. [15] Department of Medical Imaging, Hematology, and Oncology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil. [16] Uniformed Services University of the Health Sciences, Bethesda, MD, USA. [17] Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, GA, USA. [18] Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, USA. [19] Department of Medicine, Division of Infectious Diseases, University of Alabama at Birmingham, Birmingham, AL, USA. [20] Department of Internal Medicine, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil. [21] Toronto Centre for Liver Disease, Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada.;Department of Immunology, University of Toronto, Toronto, Ontario, Canada. [22] Division of Cellular Polarity and Viral Infection, German Cancer Research Center (DKFZ), Heidelberg, Germany. [23] Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA. [24] Cancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD, USA. [25] Genome Opinion, Inc., Seoul, Republic of Korea. [26] Divisions of Infectious Diseases and Organ Transplantation, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. [27] Department of Obstetrics & Gynecology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. [28] Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.;Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea. [29] Department of Genetics, University of Alabama at Birmingham, Birmingham, AL, USA. [30] Department of Medicine and Program in Mendelian Genetics, Weill Cornell Medicine, New York, NY, USA. [31] Department of Medicine, Infectious Diseases Division, Howard University Hospital, Howard University College of Medicine, Washington, DC, USA. [32] Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA. [33] Division of HIV, Infectious Diseases and Global Medicine, University of California, San Francisco, CA, USA. [34] Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. [35] Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA. [36] Laboratory of Genetic Susceptibility, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA. [37] Department of Biochemistry and Molecular Biology, National Human Genome Center, Howard University College of Medicine, Washington, DC, USA. [38] Veterans Affairs Medical Center, Washington, DC, USA. [39] Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA. [40] Department of Medicine, Division of Allergy and Immunology, Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. [41] Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA. [42] Department of Molecular Genetics and Microbiology, College of Medicine, University of Florida, Gainesville, FL, USA.;Division of Cellular Polarity and Viral Infection, German Cancer Research Center (DKFZ), Heidelberg, Germany.;Department of Infectious Diseases, Virology, University Hospital Heidelberg, Heidelberg, Germany. [43] Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA. prokuninal@mail.nih.gov. [44]
DOI 10.1038/s41588-022-01113-z
PMID 35835913
发布时间 2024-09-23
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