Spatial organization of hydrophobic and charged residues affects protein thermal stability and binding affinity.

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第一作者： Fausta,Desantis

第一单位： Center for Life Nano and Neuro Science, Istituto Italiano di Tecnologia (IIT), Viale Regina Elena 291, 00161, Rome, Italy.

作者： Fausta,Desantis ^[1] ; Mattia,Miotto ^[2] ; Lorenzo,Di Rienzo ^[3] ; Edoardo,Milanetti ^[1] ; Giancarlo,Ruocco ^[1]

作者单位： Center for Life Nano and Neuro Science, Istituto Italiano di Tecnologia (IIT), Viale Regina Elena 291, 00161, Rome, Italy. ^[1] The Open University Affiliated Research Centre at Istituto Italiano di Tecnologia, Via Morego, 30, 16163, Genoa, Italy. ^[2] Center for Life Nano and Neuro Science, Istituto Italiano di Tecnologia (IIT), Viale Regina Elena 291, 00161, Rome, Italy. mattia.miotto@roma1.infn.it. ^[3] Department of Physics, Sapienza University of Rome, Piazzale Aldo Moro, 5, 00185, Rome, Italy. ^[4]

主题词氨基酸类(Amino Acids);亲水和疏水相互作用(Hydrophobic and Hydrophilic Interactions);膜蛋白质类(Membrane Proteins);蛋白质结合(Protein Binding);蛋白质稳定性(Protein Stability);热力学(Thermodynamics)

DOI 10.1038/s41598-022-16338-5

PMID 35840609

发布时间 2022-11-15

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准确一般字义偏差语意偏离译文作用小提交