Biomarker discovery for practice of precision medicine in hypopharyngeal cancer: a theranostic study on response prediction of the key therapeutic agents.

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作者： Yumiko,Kawata-Shimamura ^[1] ; Hidetaka,Eguchi ^[2] ; Reika,Kawabata-Iwakawa ^[3] ; Mitsuhiko,Nakahira ^[2] ; Yasushi,Okazaki ^[4] ; Tetsuya,Yoda ^[5] ; Reidar,Grénman ^[1] ; Masashi,Sugasawa ^[2] ; Masahiko,Nishiyama ^[4]

作者单位： Department of Head and Neck Surgery, Saitama Medical University International Medical Center, 1397-1 Yamane, Hidaka, Saitama, 350-1298, Japan. ^[1] Research Center for Genomic Medicine, Saitama Medical University, 1397-1 Yamane, Hidaka, Saitama, 350-1298, Japan. ^[2] Department of Oral Surgery, Saitama Medical University, 38 Morohongo, Moroyama-machi, Iruma-gun, Saitama, 350-0495, Japan. ^[3] Intractable Disease Research Center, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan. ^[4] Division of Integrated Oncology Research, Gunma University Initiative for Advanced Research, 3-39-22 Showa-machi, Maebashi, Gunma, 371-8511, Japan. ^[5] Department of Maxillofacial Surgery, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8549, Japan. ^[6] Department of Otorhinolaryngology-Head and Neck Surgery, University of Turku and Turku University Hospital, PO Box 52, 20521, Turku, Finland. ^[7] Research Center for Genomic Medicine, Saitama Medical University, 1397-1 Yamane, Hidaka, Saitama, 350-1298, Japan. m.nishiyama@gunma-u.ac.jp. ^[8] Gunma University, 3-39-22 Showa-machi, Maebashi, Gunma, 371-8511, Japan. m.nishiyama@gunma-u.ac.jp. ^[9] Higashi Sapporo Hospital, 7-35, 3-3 Higashi-Sapporo, Shiroishi-ku, Sapporo, 003-8585, Japan. m.nishiyama@gunma-u.ac.jp. ^[10]

关键词 Drug therapy Hypopharyngeal cancer Molecular target Precision medicine Predictive biomarker of response

主题词细胞黏附分子, 神经元(Cell Adhesion Molecules, Neuronal);顺铂(Cisplatin);氟尿嘧啶(Fluorouracil);人类(Humans);下咽肿瘤(Hypopharyngeal Neoplasms);黏蛋白质类(Mucoproteins);癌基因蛋白质类(Oncogene Proteins)

DOI 10.1186/s12885-022-09853-1

PMID 35841085

发布时间 2022-07-19

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