首页> Structure (London, England : 1993)> Vaccine-elicited murine antibody WS6 neutralizes diverse beta-coronaviruses by recognizing a helical stem supersite of vulnerability.

Vaccine-elicited murine antibody WS6 neutralizes diverse beta-coronaviruses by recognizing a helical stem supersite of vulnerability.

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第一作者： Wei,Shi

第一单位： Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

作者： Wei,Shi ^[1] ; Lingshu,Wang ^[1] ; Tongqing,Zhou ^[1] ; Mallika,Sastry ^[1] ; Eun Sung,Yang ^[1] ; Yi,Zhang ^[1] ; Man,Chen ^[1] ; Xuejun,Chen ^[1] ; Misook,Choe ^[1] ; Adrian,Creanga ^[1] ; Kwan,Leung ^[1] ; Adam S,Olia ^[1] ; Amarendra,Pegu ^[1] ; Reda,Rawi ^[1] ; Arne,Schön ^[2] ; Chen-Hsiang,Shen ^[1] ; Erik-Stephane D,Stancofski ^[1] ; Chloe Adrienna,Talana ^[1] ; I-Ting,Teng ^[1] ; Shuishu,Wang ^[1] ; Kizzmekia S,Corbett ^[1] ; Yaroslav,Tsybovsky ^[3] ; John R,Mascola ^[4] ; Peter D,Kwong ^[5]

作者单位： Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. ^[1] Department of Biology, Johns Hopkins University, Baltimore, MD 21218, USA. ^[2] Electron Microscopy Laboratory, Cancer Research Technology Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA. ^[3] Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: jmascola@icloud.com. ^[4] Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: pdkwong@nih.gov. ^[5]

关键词 COVID-19 S2-directed antibody SARS-CoV-2 beta-coronavirus broadly neutralizing antibody crystal structure vaccine design

医学主题词动物(Animals);抗体, 中和(Antibodies, Neutralizing);抗体, 病毒(Antibodies, Viral);小鼠(Mice);疫苗(Vaccines)

DOI 10.1016/j.str.2022.06.004

PMID 35841885

发布时间 2025-05-30

基金项目

HHSN261200800001C/RC/CCR NIH HHS/United States HHSN261200800001E/CA/NCI NIH HHS/United States

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