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Adipose methylome integrative-omic analyses reveal genetic and dietary metabolic health drivers and insulin resistance classifiers.

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第一作者： Colette,Christiansen

第一单位： Department of Twin Research and Genetic Epidemiology, King's College London, London, UK. colette.christiansen@kcl.ac.uk.

作者： Colette,Christiansen ^[1] ; Max,Tomlinson ^[2] ; Melissa,Eliot ^[3] ; Emma,Nilsson ^[4] ; Ricardo,Costeira ^[5] ; Yujing,Xia ^[5] ; Sergio,Villicaña ^[5] ; Olatz,Mompeo ^[5] ; Philippa,Wells ^[5] ; Juan,Castillo-Fernandez ^[5] ; Louis,Potier ^[6] ; Marie-Claude,Vohl ^[7] ; Andre,Tchernof ^[8] ; Julia El-Sayed,Moustafa ^[5] ; Cristina,Menni ^[5] ; Claire J,Steves ^[5] ; Karl,Kelsey ^[3] ; Charlotte,Ling ^[4] ; Elin,Grundberg ^[9] ; Kerrin S,Small ^[5] ; Jordana T,Bell ^[10]

作者单位： Department of Twin Research and Genetic Epidemiology, King's College London, London, UK. colette.christiansen@kcl.ac.uk. ^[1] Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.;Department of Medical & Molecular Genetics, King's College London, London, UK. ^[2] Department of Epidemiology, Brown University School of Public Health, Providence, R.I., USA. ^[3] Epigenetics and Diabetes Unit, Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, Scania University Hospital, Malmö, Sweden. ^[4] Department of Twin Research and Genetic Epidemiology, King's College London, London, UK. ^[5] Diabetology Department, Bichat Hospital, AP-HP, Université de Paris, Paris, France. ^[6] Institute of Nutrition and Functional Foods (INAF), Université Laval, Québec, QC, Canada. ^[7] Québec Heart and Lung Institute, Université Laval, Québec, QC, Canada. ^[8] Genomic Medicine Center, Children's Mercy Research Institute, Children's Mercy Kansas City, Kansas City, MO, 64108, USA. ^[9] Department of Twin Research and Genetic Epidemiology, King's College London, London, UK. jordana.bell@kcl.ac.uk. ^[10]

关键词 Adiposity DNA methylation Integrative omics Visceral fat

医学主题词人体质量指数(Body Mass Index);DNA甲基化(DNA Methylation);膳食(Diet);后成说, 遗传(Epigenesis, Genetic);人类(Humans);胰岛素抗药性(Insulin Resistance)

DOI 10.1186/s13073-022-01077-z

PMID 35843982

发布时间 2025-05-30

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