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首页> Drug development research> T-17, a novel cyclin-dependent kinases/histone deacetylases dual inhibitor, induces cancer cells death through cell cycle arrest and apoptosis.

T-17, a novel cyclin-dependent kinases/histone deacetylases dual inhibitor, induces cancer cells death through cell cycle arrest and apoptosis.

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作者： Lin,Zhang ^[1] ; Rui,Long ^[2] ; Xiaoli,Li ^[3] ; Junhao,Jiang ^[1] ; Huali,Chen ^[1] ; Binghua,Tian ^[1] ; Binyu,Long ^[1] ; Yu,Yu ^[1] ; Zongjie,Gan ^[1]

作者单位： Department of Medicinal Chemistry, College of Pharmacy, Chongqing Medical University, Chongqing, China. ^[1] Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China. ^[2] Department of Pharmacy, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. ^[3]

关键词 CDKs HDACs T-17 cell apoptosis cell cycle dual inhibitor

主题词组蛋白脱乙酰基酶类(Histone Deacetylases);细胞系, 肿瘤(Cell Line, Tumor);细胞凋亡(Apoptosis);组蛋白脱乙酰基酶抑制剂(Histone Deacetylase Inhibitors);细胞增殖(Cell Proliferation);蛋白激酶抑制剂(Protein Kinase Inhibitors);细胞周期(Cell Cycle);细胞周期蛋白质依赖激酶类(Cyclin-Dependent Kinases);抗肿瘤药(Antineoplastic Agents);肿瘤(Neoplasms)

DOI 10.1002/ddr.21977

PMID 35844039

发布时间 2022-12-14

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Drug development research

Drug development research

2022年83卷7期

1578-1588页

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