Antileukemic effects of topoisomerase I inhibitors mediated by de-SUMOylase SENP1.

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第一作者： Qun,Niu

第一单位： Clinical Research Center, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

作者： Qun,Niu ^[1] ; Wanxin,Hou ^[2] ; Yinjie,Yan ^[3] ; Shuzhang,Sun ^[1] ; Yanyan,Lin ^[4] ; Houshun,Fang ^[4] ; Chunshuang,Ma ^[4] ; Changsheng,Dong ^[5] ; Yixuan,Cheng ^[1] ; Yan,Xu ^[4] ; Ming,Ding ^[4] ; Shuxuan,Wang ^[4] ; Zhiyan,Cui ^[4] ; Yao,Chen ^[4] ; Hegen,Li ^[6] ; Hui,Li ^[7] ; Ning,Xiao ^[8]

作者单位： Clinical Research Center, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China. ^[1] Department of Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China. ^[2] Department of Orthopaedics, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China. ^[3] Key Laboratory of Pediatric Hematology and Oncology Ministry of Health, Pediatric Translational Medicine Institute, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. ^[4] Cancer Institute of Traditional Chinese Medicine, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China. ^[5] Department of Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China. Electronic address: Shlaogen@163.com. ^[6] Key Laboratory of Pediatric Hematology and Oncology Ministry of Health, Pediatric Translational Medicine Institute, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Department of Pharmacology and Chemical Biology, School of Basic Medicine and Collaborative Innovation Center for Translational Medicine, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Fujian Children's Hospital, Fujian Branch of Shanghai Children's Medical Center Affiliated to Shanghai Jiao Tong University School of Medicine, Fujian, China. Electronic address: lihui@scmc.com.cn. ^[7] Clinical Research Center, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China. Electronic address: xiaoning86@sjtu.edu.cn. ^[8]

关键词 7-ethylcamptothecin Acute lymphoblastic leukemia SENP1 TOP1 Topotecan

主题词半胱氨酸内肽酶类(Cysteine Endopeptidases);DNA拓扑异构酶类, Ⅰ型(DNA Topoisomerases, Type I);SUMO化(Sumoylation);拓扑异构酶I抑制剂(Topoisomerase I Inhibitors);托泊替坎(Topotecan)

DOI 10.1016/j.bbadis.2022.166492

PMID 35850175

发布时间 2022-12-06

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Biochimica et biophysica acta. Molecular basis of disease

2022年1868卷12期

166492页

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Antileukemic effects of topoisomerase I inhibitors mediated by de-SUMOylase SENP1.

Biochimica et biophysica acta. Molecular basis of disease

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Biochimica et biophysica acta. Molecular basis of disease

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Antileukemic effects of topoisomerase I inhibitors mediated by de-SUMOylase SENP1.

Biochimica et biophysica acta. Molecular basis of disease

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Biochimica et biophysica acta. Molecular basis of disease

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