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Disruption of vitamin A homeostasis by the biocide tetrakis(hydroxymethyl) phosphonium sulphate in pregnant rabbits.

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第一作者： Natalia,Estrada-Ortiz

第一单位： Groningen Research Institute of Pharmacy (GRIP), University of Groningen, Groningen, The Netherlands.

作者： Natalia,Estrada-Ortiz ^[1] ; Viktoriia,Starokozhko ^[1] ; Hidde,van Steenwijk ^[1] ; Cor,van der Heide ^[1] ; Hjalmar,Permentier ^[1] ; Lisanne,van Heemskerk ^[1] ; Grietje Harmanna,Prins ^[1] ; Janette,Heegsma ^[2] ; Klaas Nico,Faber ^[2] ; Steffi,Bressers ^[3] ; Guy,Steiblen ^[4] ; Antoinette,de Groot ^[5] ; Steve,Groome ^[6] ; Erik,van Miert ^[5] ; Geny,Groothuis ^[1] ; Inge Anne Maria,de Graaf ^[7]

作者单位： Groningen Research Institute of Pharmacy (GRIP), University of Groningen, Groningen, The Netherlands. ^[1] Department of Gastroenterology and Hepatology, University of Groningen, University Medi-cal Center Groningen, Groningen, The Netherlands. ^[2] Charles River Laboratories, 's-Hertogenbosch, The Netherlands. ^[3] Solvay, Toxicological and Environmental Risk Assessment Unit, Genas, France. ^[4] Solvay, Toxicological and Environmental Risk Assessment Unit, Bruxelles, Belgium. ^[5] Solvay, Product Stewardship, Oldbury, UK. ^[6] University Medical Center Groningen, Surgical Research Laboratory, University of Groningen, Groningen, The Netherlands.;School of Science and Engineering, University of Groningen, Groningen, The Netherlands. ^[7]

关键词 THPS VAD cytochrome p45026A1 precision-cut liver slices retinoid binding proteins retinoids teratogenicity tetrakis(hydroxymethyl) phosphonium sulphate vitamin A homeostasis