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ACE2-binding exposes the SARS-CoV-2 fusion peptide to broadly neutralizing coronavirus antibodies.

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第一作者: Jun Siong,Low
第一单位: Institute for Research in Biomedicine, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland.;Institute of Microbiology, ETH Zürich, 8093 Zurich, Switzerland.
作者单位: Institute for Research in Biomedicine, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland.;Institute of Microbiology, ETH Zürich, 8093 Zurich, Switzerland. [1] Department of Biochemistry, University of Washington, Seattle, WA 98195, USA. [2] Humabs BioMed SA (subsidiary of Vir Biotechnology), 6500 Bellinzona, Switzerland. [3] Institute for Research in Biomedicine, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland. [4] KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, B-3000 Leuven, Belgium. [5] KU Leuven Department of Imaging and Pathology, Translational Cell and Tissue Research, B-3000 Leuven, Belgium. [6] Vir Biotechnology, San Francisco, CA 94158, USA. [7] Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.;Howard Hughes Medical Institute, Seattle, WA 98195, USA. [8] Clinic of Internal Medicine and Infectious Diseases, Clinica Luganese Moncucco, 6900 Lugano, Switzerland. [9] Faculty of Biomedical Sciences, Università della Svizzera Italiana, 6900 Lugano, Switzerland.;Department of Internal Medicine, Ente Ospedaliero Cantonale, 6500 Bellinzona, Switzerland.;Prince of Wales Hospital Clinical School, University of New South Wales, Sydney, New South Wales 2052, Australia. [10] Faculty of Biomedical Sciences, Università della Svizzera Italiana, 6900 Lugano, Switzerland.;Division of Clinical Pharmacology and Toxicology, Institute of Pharmacological Sciences of Southern Switzerland, Ente Ospedaliero Cantonale, 6900 Lugano, Switzerland.;Clinical Trial Unit, Ente Ospedaliero Cantonale, 6500 Bellinzona, Switzerland.;Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, 8091 Zurich, Switzerland. [11] KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, B-3000 Leuven, Belgium.;Global Virus Network, Baltimore, MD 21201, USA. [12] Humabs BioMed SA (subsidiary of Vir Biotechnology), 6500 Bellinzona, Switzerland.;National Institute of Molecular Genetics, 20122 Milano, Italy. [13]
DOI 10.1126/science.abq2679
PMID 35857703
发布时间 2025-10-31
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