Pharmacologic modulation of intracellular Na<sup>+</sup> concentration with ranolazine impacts inflammatory response in humans and mice.

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作者： Max,Lenz ^[1] ; Manuel,Salzmann ^[2] ; Cosmin I,Ciotu ^[1] ; Christoph,Kaun ^[2] ; Konstantin A,Krychtiuk ^[3] ; Andreja,Rehberger Likozar ^[1] ; Miran,Sebestjen ^[1] ; Laura,Goederle ^[4] ; Sabine,Rauscher ^[4] ; Zoriza,Krivaja ^[5] ; Christoph J,Binder ^[6] ; Kurt,Huber ^[7] ; Christian,Hengstenberg ^[8] ; Bruno K,Podesser ^[1] ; Michael J M,Fischer ^[7] ; Johann,Wojta ^[9] ; Philipp J,Hohensinner ^[1] ; Walter S,Speidl ^[2]

作者单位： Department of Internal Medicine II - Division of Cardiology, Medical University of Vienna, 1090 Vienna, Austria. ^[1] Ludwig Boltzmann Institute for Cardiovascular Research, A-1090 Vienna, Austria. ^[2] Center of Physiology and Pharmacology, Medical University of Vienna, 1090 Vienna, Austria. ^[3] Department of Vascular Disease, University Medical Centre Ljubljana, 1000 Ljubljana, Slovenia. ^[4] Department of Cardiology, University Medical Centre Ljubljana, 1000 Ljubljana, Slovenia. ^[5] Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, Slovenia. ^[6] Department of Laboratory Medicine, Medical University of Vienna, 1090 Vienna, Austria. ^[7] Core Facility Imaging, Medical University of Vienna, 1090 Vienna, Austria. ^[8] 3rd Medical Department, Cardiology and Intensive Care Medicine, Clinic Ottakring (Wilhelminenhospital), and Sigmund Freud University, Medical Faculty, Vienna, 1020 Austria. ^[9] Center for Biomedical Research, Medical University of Vienna, 1090 Vienna, Austria. ^[10]

关键词 Atherosclerosis Endothelium Inflammation NF-κB Ranolazine