Enhancing glycosylase base-editor activity by fusion to transactivation modules.

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作者： Xingxiao,Dong ^[1] ; Chao,Yang ^[2] ; Zhenzhen,Ma ^[3] ; Ming,Chen ^[4] ; Xueli,Zhang ^[5] ; Changhao,Bi ^[6]

作者单位： School of Biological Engineering, Dalian Polytechnic University, Dalian, China. ^[1] Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China; Key Laboratory of Systems Microbial Biotechnology, Chinese Academy of Sciences, Tianjin, China. ^[2] College of Life Sciences, Nankai University, Tianjin, China. ^[3] School of Biological Engineering, Dalian Polytechnic University, Dalian, China. Electronic address: chenming@dlpu.edu.cn. ^[4] Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China; Key Laboratory of Systems Microbial Biotechnology, Chinese Academy of Sciences, Tianjin, China. Electronic address: zhang_xl@tib.cas.cn. ^[5] Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China; Key Laboratory of Systems Microbial Biotechnology, Chinese Academy of Sciences, Tianjin, China. Electronic address: bi_ch@tib.cas.cn. ^[6]

关键词 CP: Molecular biology CRISPR-Cas9 base editor glycosylase base editor transactivation modules

主题词 HEK293细胞(HEK293 Cells);人类(Humans);突变(Mutation);转录激活(Transcriptional Activation)

DOI 10.1016/j.celrep.2022.111090

PMID 35858572

发布时间 2022-09-27

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