Targeting Myeloid Checkpoint Molecules in Combination With Antibody Therapy: A Novel Anti-Cancer Strategy With IgA Antibodies?

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第一作者： Chilam,Chan

第一单位： Center for Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands.

作者： Chilam,Chan ^[1] ; Marta,Lustig ^[2] ; Niklas,Baumann ^[2] ; Thomas,Valerius ^[2] ; Geert,van Tetering ^[1] ; Jeanette H W,Leusen ^[1]

作者单位： Center for Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands. ^[1] Division of Stem Cell Transplantation and Immunotherapy, Department of Medicine II, Christian Albrechts University Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany. ^[2]

关键词 CD47-SIRPalpha axis IgA antibodies cancer immonotherapy immune checkpoint macrophages myeloid checkpoints neutrophils (PMNs)

主题词抗原, 分化(Antigens, Differentiation);人类(Humans);免疫球蛋白A(Immunoglobulin A);免疫球蛋白G(Immunoglobulin G);肿瘤(Neoplasms);吞噬作用(Phagocytosis);受体, 免疫(Receptors, Immunologic)

DOI 10.3389/fimmu.2022.932155

PMID 35865547

发布时间 2022-09-30

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