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A clade C HIV-1 vaccine protects against heterologous SHIV infection by modulating IgG glycosylation and T helper response in macaques.

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第一作者： Anusmita,Sahoo

第一单位： Emory Vaccine Center, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.;Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA.

作者： Anusmita,Sahoo ^[1] ; Andrew T,Jones ^[1] ; Narayanaiah,Cheedarla ^[1] ; Sailaja,Gangadhara ^[1] ; Vicky,Roy ^[2] ; Tiffany M,Styles ^[1] ; Ayalnesh,Shiferaw ^[1] ; Korey L,Walter ^[3] ; LaTonya D,Williams ^[4] ; Xiaoying,Shen ^[4] ; Gabriel,Ozorowski ^[5] ; Wen-Hsin,Lee ^[5] ; Samantha,Burton ^[6] ; Lasanajak,Yi ^[7] ; Xuezheng,Song ^[7] ; Zhaohui S,Qin ^[8] ; Cynthia A,Derdeyn ^[9] ; Andrew B,Ward ^[5] ; John D,Clements ^[10] ; Raghavan,Varadarajan ^[11] ; Georgia D,Tomaras ^[4] ; Pamela A,Kozlowski ^[3] ; Galit,Alter ^[2] ; Rama Rao,Amara ^[1]

作者单位： Emory Vaccine Center, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.;Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA. ^[1] Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA. ^[2] Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA. ^[3] Department of Surgery, Duke University Medical School, Duke University, Durham, NC 27710, USA. ^[4] Department of Integrative Structural and Computational Biology, Scripps Research Institute, San Diego, CA 92121, USA. ^[5] Emory Vaccine Center, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA. ^[6] Department of Biochemistry, Emory Glycomics and Molecular Interactions Core (EGMIC), School of Medicine, Emory University, Atlanta, GA 30322, USA. ^[7] Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA. ^[8] Emory Vaccine Center, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.;Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, GA 30322, USA. ^[9] Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA 8638, USA. ^[10] Molecular Biophysics Unit (MBU), Indian Institute of Science, Bengaluru, Karnataka 560012, India.;Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bengaluru, Karnataka 560012, India. ^[11]

医学主题词艾滋病疫苗(AIDS Vaccines);动物(Animals);CD8阳性T淋巴细胞(CD8-Positive T-Lymphocytes);糖基化(Glycosylation);HIV-1(HIV-1);免疫球蛋白G(Immunoglobulin G);猕猴(Macaca mulatta);T淋巴细胞, 辅助诱导(T-Lymphocytes, Helper-Inducer);肿瘤坏死因子α(Tumor Necrosis Factor-alpha);痘苗病毒(Vaccinia virus)

DOI 10.1126/sciimmunol.abl4102

PMID 35867800

发布时间 2025-10-31

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A clade C HIV-1 vaccine protects against heterologous SHIV infection by modulating IgG glycosylation and T helper response in macaques.

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A clade C HIV-1 vaccine protects against heterologous SHIV infection by modulating IgG glycosylation and T helper response in macaques.

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