Inefficiency of two-stage designs in phase II oncology clinical trials with high proportion of inevaluable patients.

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第一作者： Lingyun,Ji

第一单位： Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States of America. Electronic address: lji@usc.edu.

作者： Lingyun,Ji ^[1] ; Jennifer,Whangbo ^[2] ; John E,Levine ^[3] ; Todd A,Alonzo ^[4]

作者单位： Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States of America. Electronic address: lji@usc.edu. ^[1] Division of Hematology-Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, United States of America. ^[2] Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States of America. ^[3] Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States of America. ^[4]

关键词 Accrual suspension Inefficiency Inevaluable Phase II design Two-stage design

主题词计算机模拟(Computer Simulation);人类(Humans);医学肿瘤学(Medical Oncology);肿瘤(Neoplasms);研究设计(Research Design);样本大小(Sample Size)

DOI 10.1016/j.cct.2022.106849

PMID 35868503

发布时间 2023-09-02

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