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Mechanistic insights on novel small molecule allosteric activators of cGMP-dependent protein kinase PKG1α.

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第一作者： Paul,Tawa

第一单位： Mass Spectrometry & Biophysics, Computational & Structural Chemistry, Merck & Co, Inc, Kenilworth, New Jersey, USA.

作者： Paul,Tawa ^[1] ; Lei,Zhang ^[2] ; Essam,Metwally ^[3] ; Yan,Hou ^[1] ; Mark A,McCoy ^[1] ; W Michael,Seganish ^[4] ; Rumin,Zhang ^[1] ; Emily,Frank ^[5] ; Payal,Sheth ^[1] ; Jennifer,Hanisak ^[6] ; Christopher,Sondey ^[7] ; David,Bauman ^[8] ; Aileen,Soriano ^[9]

作者单位： Mass Spectrometry & Biophysics, Computational & Structural Chemistry, Merck & Co, Inc, Kenilworth, New Jersey, USA. ^[1] Biologics AR&D Immunoassay Group, Merck & Co, Inc, Kenilworth, New Jersey, USA. ^[2] Computational & Structural Chemistry, Merck & Co, Inc, South San Francisco, California, USA. ^[3] Discovery Chemistry, Merck & Co, Inc, South San Francisco, California, USA. ^[4] Quantitative Biosciences, Merck & Co, Inc, Kenilworth, New Jersey, USA. ^[5] Discovery Chemistry, Merck & Co, Inc, Kenilworth, New Jersey, USA. ^[6] Quantitative Biosciences, Merck & Co, Inc, Boston, Massachusetts, USA. ^[7] Discovery Biology, Merck & Co, Inc, Kenilworth, New Jersey, USA. ^[8] Mass Spectrometry & Biophysics, Computational & Structural Chemistry, Merck & Co, Inc, Kenilworth, New Jersey, USA. Electronic address: aileen.soriano@merck.com. ^[9]

关键词 allosteric regulation cGMP cGMP-dependent protein kinase cardiovascular disease drug discovery enzyme catalysis kinase activators protein kinase G