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Structure-based prediction of BRAF mutation classes using machine-learning approaches.

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第一作者： Fanny S,Krebs

第一单位： Computer-Aided Molecular Engineering Group, Department of Oncology UNIL-CHUV, University of Lausanne, Epalinges, Switzerland.

作者： Fanny S,Krebs ^[1] ; Christian,Britschgi ^[2] ; Sylvain,Pradervand ^[3] ; Rita,Achermann ^[4] ; Petros,Tsantoulis ^[5] ; Simon,Haefliger ^[6] ; Andreas,Wicki ^[2] ; Olivier,Michielin ^[7] ; Vincent,Zoete ^[8]

作者单位： Computer-Aided Molecular Engineering Group, Department of Oncology UNIL-CHUV, University of Lausanne, Epalinges, Switzerland. ^[1] Department of Medical Oncology and Hematology, University Hospital Zurich, Comprehensive Cancer Center Zurich, University of Zurich, Zurich, Switzerland. ^[2] Center for Precision Oncology, Department of Oncology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland. ^[3] Department of Radiology, Clinic of Radiology and Nuclear Medicine, University Hospital Basel, University of Basel, Basel, Switzerland. ^[4] Department of Oncology, Hôpitaux Universitaires de Genève, University of Geneva, Geneva, Switzerland. ^[5] Department of Medical Oncology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland. ^[6] Molecular Modelling Group, SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland.;Center for Precision Oncology, Department of Oncology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland. ^[7] Computer-Aided Molecular Engineering Group, Department of Oncology UNIL-CHUV, University of Lausanne, Epalinges, Switzerland. Vincent.zoete@unil.ch.;Molecular Modelling Group, SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland. Vincent.zoete@unil.ch. ^[8]

医学主题词人类(Humans);MAP激酶信号系统(MAP Kinase Signaling System);突变(Mutation);突变, 误义(Mutation, Missense);原癌基因蛋白质B-raf(Proto-Oncogene Proteins B-raf)

DOI 10.1038/s41598-022-16556-x

PMID 35869122

发布时间 2022-10-03

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