Enhanced cytotoxicity of a novel family of ATPase inhibitors in colorectal cancer cells with high NAT2 activity.

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作者： Xiaonan,Zhang ^[1] ; Ece,Akcan ^[1] ; Mario,Correia ^[2] ; Natallia,Rameika ^[1] ; Snehangshu,Kundu ^[1] ; Ivaylo,Stoimenov ^[1] ; Veronica,Rendo ^[3] ; Anna U,Eriksson ^[4] ; Martin,Haraldsson ^[5] ; Daniel,Globisch ^[2] ; Tobias,Sjöblom ^[6]

作者单位： Department of Immunology, Genetics and Pathology, Uppsala University, SE-751 85 Uppsala, Sweden. ^[1] Department of Chemistry, BMC, Science for Life Laboratory, Uppsala University, SE-751 24 Uppsala, Sweden. ^[2] Department of Immunology, Genetics and Pathology, Uppsala University, SE-751 85 Uppsala, Sweden; Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA, 02215, USA. ^[3] Department of Chemistry, CBCS, KBC-C4, Umeå University, SE-901 87 UMEÅ, Sweden. ^[4] Chemical Biology Consortium Sweden (CBCS), Science for Life Laboratory, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden. ^[5] Department of Immunology, Genetics and Pathology, Uppsala University, SE-751 85 Uppsala, Sweden. Electronic address: tobias.sjoblom@igp.uu.se. ^[6]

关键词 ATPase inhibitors Arylamine N acetyltransferase 2 (NAT2)Colorectal cancer Loss of heterozygosity (LOH)Nf-kB pathway Small molecule therapeutics

主题词乙酰基转移酶类(Acetyltransferases);腺苷三磷酸酶类(Adenosine Triphosphatases);等位基因(Alleles);抗肿瘤药(Antineoplastic Agents);芳基胺N-乙酰转移酶(Arylamine N-Acetyltransferase);结直肠肿瘤(Colorectal Neoplasms);人类(Humans)

DOI 10.1016/j.bcp.2022.115184

PMID 35872325

发布时间 2022-09-14

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