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Genome-wide bidirectional CRISPR screens identify mucins as host factors modulating SARS-CoV-2 infection.

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作者单位: Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA, USA. [1] Department of Bioengineering, University of California, Berkeley, Berkeley, CA, USA. [2] Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA. [3] Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA. [4] Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. [5] Marsico Lung Institute and Cystic Fibrosis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. [6] Department of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA. [7] Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT, USA. [8] Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA. [9] Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA. [10] Center for Computational Biology, University of California, Berkeley, Berkeley, CA, USA. [11] Department of Chemistry and Stanford ChEM-H, Stanford University, Stanford, CA, USA. [12] Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA. [13] Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. [14] Department of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, Stanford, CA, USA. [15] The Henry Wheeler Center for Emerging and Neglected Diseases, Berkeley, CA, USA. [16] Department of Genetics, University of Texas MD Anderson Cancer Center, Houston, TX, USA. [17] Department of Regenerative and Cancer Cell Biology, Albany Medical College, Albany, NY, USA. [18] Chan Zuckerberg Biohub, San Francisco, CA, USA. [19] Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA. [20] Howard Hughes Medical Institute, Stanford University, Stanford, CA, USA. [21] Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA. [22] Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA, USA. eharris@berkeley.edu. [23] Department of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA. silvanak@stanford.edu. [24] Arc Institute, Palo Alto, CA, USA. silvanak@stanford.edu. [25] Department of Bioengineering, University of California, Berkeley, Berkeley, CA, USA. pdhsu@berkeley.edu. [26] Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA. pdhsu@berkeley.edu. [27] Center for Computational Biology, University of California, Berkeley, Berkeley, CA, USA. pdhsu@berkeley.edu. [28] Arc Institute, Palo Alto, CA, USA. pdhsu@berkeley.edu. [29]
DOI 10.1038/s41588-022-01131-x
PMID 35879412
发布时间 2022-12-12
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