首页> Alzheimer's research & therapy> A multiscale brain network model links Alzheimer's disease-mediated neuronal hyperactivity to large-scale oscillatory slowing.

A multiscale brain network model links Alzheimer's disease-mediated neuronal hyperactivity to large-scale oscillatory slowing.

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第一作者： Anne M,van Nifterick

第一单位： Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands. a.vannifterick@amsterdamumc.nl.;Clinical Neurophysiology and MEG Center, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands. a.vannifterick@amsterdamumc.nl.;Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands. a.vannifterick@amsterdamumc.nl.

作者： Anne M,van Nifterick ^[1] ; Alida A,Gouw ^[2] ; Ronald E,van Kesteren ^[3] ; Philip,Scheltens ^[4] ; Cornelis J,Stam ^[5] ; Willem,de Haan ^[2]

作者单位： Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands. a.vannifterick@amsterdamumc.nl.;Clinical Neurophysiology and MEG Center, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands. a.vannifterick@amsterdamumc.nl.;Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands. a.vannifterick@amsterdamumc.nl. ^[1] Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.;Clinical Neurophysiology and MEG Center, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.;Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands. ^[2] Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands.;Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. ^[3] Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.;Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands. ^[4] Clinical Neurophysiology and MEG Center, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.;Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands. ^[5]

关键词 Alzheimer’s disease Computational modeling Hyperexcitability MEG Neural mass models Neuronal network Oscillatory slowing

医学主题词阿尔茨海默病(Alzheimer Disease);脑(Brain);计算机模拟(Computer Simulation);人类(Humans);脑磁图描记术(Magnetoencephalography);模型, 神经学(Models, Neurological);神经元(Neurons)

DOI 10.1186/s13195-022-01041-4

PMID 35879779

发布时间 2025-10-31

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准确一般字义偏差语意偏离译文作用小提交