The repression of oncoprotein SET by the tumor suppressor p53 reveals a p53-SET-PP2A feedback loop for cancer therapy.

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第一作者： Han,Yao

第一单位： State Key Laboratory of Medical Molecular Biology & Department of Medical Genetics, Institute of Basic Medical Sciences & School of Basic Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, China.

作者： Han,Yao ^[1] ; Wenbin,Xu ^[1] ; Yajing,Liu ^[1] ; Zhijie,Cao ^[1] ; Jia,Wen ^[1] ; Mi,Zhang ^[2] ; Zhen,Wu ^[1] ; Xiaojun,Yan ^[1] ; Zishan,Jiao ^[1] ; Zijing,Zhang ^[1] ; Jianyuan,Chen ^[1] ; Meng,Zhang ^[1] ; Wei-Guo,Zhu ^[3] ; Donglai,Wang ^[4]

作者单位： State Key Laboratory of Medical Molecular Biology & Department of Medical Genetics, Institute of Basic Medical Sciences & School of Basic Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, China. ^[1] Department of Anatomy, Histology and Embryology, School of Basic Medicine, China Medical University, Shenyang, 110122, China. ^[2] Department of Biochemistry and Molecular Biology, Shenzhen University School of Medicine, Shenzhen, 518060, China. zhuweiguo@szu.edu.cn. ^[3] State Key Laboratory of Medical Molecular Biology & Department of Medical Genetics, Institute of Basic Medical Sciences & School of Basic Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, China. dwang@ibms.pumc.edu.cn. ^[4]

关键词 FTY720 PP2A SET feedback loop p53 tumor suppression

主题词肿瘤抑制蛋白质p53(Tumor Suppressor Protein p53);蛋白质磷酸酶2(Protein Phosphatase 2);反馈(Feedback);细胞系, 肿瘤(Cell Line, Tumor);癌基因蛋白质类(Oncogene Proteins);肿瘤(Neoplasms)

DOI 10.1007/s11427-021-2123-8

PMID 35881220

发布时间 2023-02-03

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Science China. Life sciences

2023年66卷1期

81-93页

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The repression of oncoprotein SET by the tumor suppressor p53 reveals a p53-SET-PP2A feedback loop for cancer therapy.

Science China. Life sciences

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The repression of oncoprotein SET by the tumor suppressor p53 reveals a p53-SET-PP2A feedback loop for cancer therapy.

Science China. Life sciences

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Science China. Life sciences

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