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Diminazene Aceturate Reduces Angiotensin II Constriction and Interacts with the Spike Protein of Severe Acute Respiratory Syndrome Coronavirus 2.

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第一作者： John M,Matsoukas

第一单位： NewDrug PC, Patras Science Park, 26500 Patras, Greece.;Institute for Health and Sport, Victoria University, Melbourne, VIC 3030, Australia.;Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada.

作者： John M,Matsoukas ^[1] ; Laura Kate,Gadanec ^[2] ; Anthony,Zulli ^[2] ; Vasso,Apostolopoulos ^[3] ; Konstantinos,Kelaidonis ^[4] ; Irene,Ligielli ^[5] ; Kalliopi,Moschovou ^[5] ; Nikitas,Georgiou ^[5] ; Panagiotis,Plotas ^[6] ; Christos T,Chasapis ^[7] ; Graham,Moore ^[8] ; Harry,Ridgway ^[9] ; Thomas,Mavromoustakos ^[5]

作者单位： NewDrug PC, Patras Science Park, 26500 Patras, Greece.;Institute for Health and Sport, Victoria University, Melbourne, VIC 3030, Australia.;Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada. ^[1] Institute for Health and Sport, Victoria University, Melbourne, VIC 3030, Australia. ^[2] Institute for Health and Sport, Victoria University, Melbourne, VIC 3030, Australia.;Immunology Program, Australian Institute for Musculoskeletal Science, Melbourne, VIC 3021, Australia. ^[3] NewDrug PC, Patras Science Park, 26500 Patras, Greece. ^[4] Department of Chemistry National and Kapodistrian, University of Athens, Zographou, 15784 Athens, Greece. ^[5] Laboratory of Primary Health Care, School of Health Rehabilitation Sciences, University of Patras, 26504 Patras, Greece. ^[6] NMR Facility, Instrumental Analysis Laboratory, School of Natural Sciences, University of Patras, 26504 Patras, Greece.;Institute of Chemical Engineering Sciences, Foundation for Research and Technology, Hellas (FORTH/ICE-HT), 26504 Patras, Greece. ^[7] Pepmetics Incorporated, 772 Murphy Pace, Victoria, BC V8Y 3H4, Canada. ^[8] Institute for Sustainable Industries and Liveable Cities, Victoria University, Melbourne, VIC 8001, Australia.;AquaMem Consultants, Rodeo, NM 88056, USA. ^[9]

关键词 ACE2 COVID-19 DIZE SARS-CoV-2 angiotensin II angiotensin type 1 receptor angiotensin-converting enzyme 2 coronavirus 2019 diminazene aceturate drug repurposing sartans severe acute respiratory syndrome coronavirus 2

DOI 10.3390/biomedicines10071731

PMID 35885036

发布时间 2022-07-31

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Diminazene Aceturate Reduces Angiotensin II Constriction and Interacts with the Spike Protein of Severe Acute Respiratory Syndrome Coronavirus 2.

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Diminazene Aceturate Reduces Angiotensin II Constriction and Interacts with the Spike Protein of Severe Acute Respiratory Syndrome Coronavirus 2.

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