A Recombinant Chimeric Protein-Based Vaccine Containing T-Cell Epitopes from Amastigote Proteins and Combined with Distinct Adjuvants, Induces Immunogenicity and Protection against <i>Leishmania infantum</i> Infection.

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第一作者： Daniela P,Lage

第一单位： Programa de Pós-Graduação em Ciências da Saúde: Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade Federal de Minas Gerais, Av. Prof. Alfredo Balena, 190, Belo Horizonte 30130-100, MG, Brazil.

作者： Daniela P,Lage ^[1] ; Danniele L,Vale ^[1] ; Flávia P,Linhares ^[1] ; Camila S,Freitas ^[1] ; Amanda S,Machado ^[1] ; Jamille M O,Cardoso ^[2] ; Daysiane,de Oliveira ^[3] ; Nathália C,Galvani ^[1] ; Marcelo P,de Oliveira ^[1] ; João A,Oliveira-da-Silva ^[1] ; Fernanda F,Ramos ^[1] ; Grasiele S V,Tavares ^[1] ; Fernanda,Ludolf ^[1] ; Raquel S,Bandeira ^[1] ; Isabela A G,Pereira ^[1] ; Miguel A,Chávez-Fumagalli ^[4] ; Bruno M,Roatt ^[2] ; Ricardo A,Machado-de-Ávila ^[3] ; Myron,Christodoulides ^[5] ; Eduardo A F,Coelho ^[1] ; Vívian T,Martins ^[6]

作者单位： Programa de Pós-Graduação em Ciências da Saúde: Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade Federal de Minas Gerais, Av. Prof. Alfredo Balena, 190, Belo Horizonte 30130-100, MG, Brazil. ^[1] Laboratório de Imunopatologia, Núcleo de Pesquisas em Ciências Biológicas (NUPEB), Departamento de Ciências Biológicas, Insituto de Ciências Exatas e Biológicas, Universidade Federal de Ouro Preto, Ouro Preto CEP 35400-000, MG, Brazil. ^[2] Programa de Pós-Graduação em Ciências da Saúde, Universidade do Extremo Sul Catarinense, Criciúma 88806-000, SC, Brazil. ^[3] Computational Biology and Chemistry Research Group, Vicerrectorado de Investigación, Universidad Católica de Santa María, Urb. San José S/N, Umacollo, Arequipa 04000, Peru. ^[4] Neisseria Research Group, Molecular Microbiology, Faculty of Medicine, School of Clinical and Experimental Sciences, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK. ^[5] Departamento de Patologia Clínica, Colégio Técnico (COLTEC), Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, Belo Horizonte 31270-901, MG, Brazil. ^[6]

关键词 T-cell epitopes adjuvants immune response polypeptide-based protein vaccine visceral leishmaniasis

DOI 10.3390/vaccines10071146

PMID 35891310

发布时间 2023-03-28

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2022年10卷7期

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A Recombinant Chimeric Protein-Based Vaccine Containing T-Cell Epitopes from Amastigote Proteins and Combined with Distinct Adjuvants, Induces Immunogenicity and Protection against <i>Leishmania infantum</i> Infection.

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A Recombinant Chimeric Protein-Based Vaccine Containing T-Cell Epitopes from Amastigote Proteins and Combined with Distinct Adjuvants, Induces Immunogenicity and Protection against <i>Leishmania infantum</i> Infection.

Vaccines

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Vaccines

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