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Elevated Myl9 reflects the Myl9-containing microthrombi in SARS-CoV-2-induced lung exudative vasculitis and predicts COVID-19 severity.

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作者单位: Department of Immunology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan. [1] Department of Pathology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan. [2] Department of Emergency and Critical Care Medicine, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan. [3] Clinical Research Center, Chiba University Hospital, Chiba 260-8677, Japan. [4] Department of Respiratory Medicine, Juntendo University Faculty of Medicine and Graduate School of Medicine, Tokyo 113-8431, Japan. [5] Department of Respiratory Medicine, Funabashi Central Hospital, Chiba 273-8556, Japan. [6] Department of Infectious Diseases, Japanese Red Cross Narita Hospital, Chiba 286-0041, Japan. [7] Department of Respiratory Medicine, Eastern Chiba Medical Center, Chiba 283-8686, Japan. [8] Department of Anesthesiology and Critical Care Medicine, School of Medicine, Fujita Health University, Aichi 470-1192, Japan. [9] Department of Pathology, School of Medicine, Fujita Health University, Aichi 470-1192, Japan. [10] Department of Respirology, Funabashi Municipal Medical CenterChiba 273-8588, Japan. [11] Department of Respirology, Kimitsu Chuo Hospital, Chiba 292-0822, Japan. [12] Department of Gastroenterology, National Hospital Organization Chiba Medical Center, Chiba 260-8606, Japan. [13] Department of Respirology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan. [14] Department of Pathology, Asahi General Hospital, Chiba 289-2511, Japan. [15] Department of Surgical Pathology, Sapporo Medical University of Medicine, Sapporo 060-8543, Japan. [16] Department of Gastroenterology and Hepatology, Sapporo Medical University of Medicine, Sapporo 060-8543, Japan. [17] DLC Research Institute LLC, Nagasaki 850-0011, Japan. [18] CNT-Application Research Center, National Institute of Advanced Industrial Science and Technology, Tsukuba 305-8565, Japan. [19] Department of Experimental Immunology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan. [20] Department of General Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan. [21] Department of Infectious Diseases, Chiba University Hospital, Chiba 260-8677, Japan. [22] COVID-19 Vaccine Center, Chiba University Hospital, Chiba 260-8677, Japan. [23] Department of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan. [24] Cellular and Molecular Biotechnology Research Institute, National Institute of Advanced Industrial Science and Technology, Tsukuba 305-8565, Japan. [25] Department of Endocrinology, Hematology, and Gerontology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan. [26] Core Research for Evolutionary Science and Technology, Japan Agency for Medical Research and Development, Chiba 260-8670, Japan. [27]
DOI 10.1073/pnas.2203437119
PMID 35895716
发布时间 2022-09-30
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Proceedings of the National Academy of Sciences of the United States of America

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