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首页> Journal of neuroinflammation> Transforming growth factor-β1 protects against LPC-induced cognitive deficit by attenuating pyroptosis of microglia via NF-κB/ERK1/2 pathways.

Transforming growth factor-β1 protects against LPC-induced cognitive deficit by attenuating pyroptosis of microglia via NF-κB/ERK1/2 pathways.

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作者： Yi,Xie ^[1] ; Xuejiao,Chen ^[1] ; Ying,Li ^[1] ; Simiao,Chen ^[2] ; Shuai,Liu ^[3] ; Zhiyuan,Yu ^[1] ; Wei,Wang ^[4]

作者单位： Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. ^[1] Department of Rehabilitation Medicine, The First Affiliated Hospital of Medical College, Zhejiang University, Hangzhou, 310003, China. ^[2] Reproductive Medicine Center, Tongji Hospital, Tongji Medicine College, Huazhong University of Science and Technology, Wuhan, 430030, China. ^[3] Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. wwang@vip.126.com. ^[4]

关键词 Cognitive deficit Demyelination LPC Microglia Neuroinflammation Pyroptosis TGF-β1

主题词动物(Animals);认知(Cognition);脱髓鞘疾病(Demyelinating Diseases);炎性体(Inflammasomes);脂多糖类(Lipopolysaccharides);溶血磷脂酰胆碱类(Lysophosphatidylcholines);MAP激酶信号系统(MAP Kinase Signaling System);小鼠(Mice);小神经胶质细胞(Microglia);NF-κB(NF-kappa B);转化生长因子β1(Transforming Growth Factor beta1)

DOI 10.1186/s12974-022-02557-0

PMID 35902863

发布时间 2022-08-03

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Journal of neuroinflammation

Journal of neuroinflammation

2022年19卷1期

194页

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