首页> Bioorganic & medicinal chemistry letters> Discovery of 2-vinyl-10H-phenothiazine derivatives as a class of ferroptosis inhibitors with minimal human Ether-a-go-go related gene (hERG) activity for the treatment of DOX-induced cardiomyopathy.

Discovery of 2-vinyl-10H-phenothiazine derivatives as a class of ferroptosis inhibitors with minimal human Ether-a-go-go related gene (hERG) activity for the treatment of DOX-induced cardiomyopathy.

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第一作者： Jing,You

第一单位： State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.

作者： Jing,You ^[1] ; Wei,Yang ^[1] ; Ronggang,Ma ^[1] ; Anjie,Xia ^[1] ; Guo,Zhang ^[1] ; Zhen,Fang ^[1] ; Nihong,Guo ^[2] ; Shengyong,Yang ^[1] ; Linli,Li ^[3]

作者单位： State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China. ^[1] Key Laboratory of Drug Targeting and Drug Delivery System of Ministry of Education, West China School of Pharmacy, Sichuan University, Sichuan 610041, China. ^[2] Key Laboratory of Drug Targeting and Drug Delivery System of Ministry of Education, West China School of Pharmacy, Sichuan University, Sichuan 610041, China. Electronic address: lilinli@scu.edu.cn. ^[3]

关键词 2-vinyl-10H-phenothiazine derivatives DOX-induced cardiomyopathy Ferroptosis inhibitor Structure-activity relationship hERG inhibition

主题词心肌疾病(Cardiomyopathies);醚类(Ethers);人类(Humans);酚噻嗪类(Phenothiazines);构效关系(Structure-Activity Relationship)

DOI 10.1016/j.bmcl.2022.128911

PMID 35907606

发布时间 2022-09-01

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