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Huntingtin turnover: modulation of huntingtin degradation by cAMP-dependent protein kinase A (PKA) phosphorylation of C-HEAT domain Ser2550.

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第一作者： Yejin,Lee

第一单位： Department of Biological Sciences, KI for the BioCentury, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Korea.;Molecular Neurogenetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.;Department of Neurology, Harvard Medical School, Boston, MA 02114, USA.

作者： Yejin,Lee ^[1] ; Hyeongju,Kim ^[2] ; Douglas,Barker ^[3] ; Ravi,Vijayvargia ^[3] ; Ranjit Singh,Atwal ^[3] ; Harrison,Specht ^[4] ; Hasmik,Keshishian ^[4] ; Steven A,Carr ^[4] ; Ramee,Lee ^[5] ; Seung,Kwak ^[5] ; Kyung-Gi,Hyun ^[3] ; Jacob,Loupe ^[3] ; Marcy E,MacDonald ^[3] ; Ji-Joon,Song ^[2] ; Ihn Sik,Seong ^[3]

作者单位： Department of Biological Sciences, KI for the BioCentury, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Korea.;Molecular Neurogenetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.;Department of Neurology, Harvard Medical School, Boston, MA 02114, USA. ^[1] Department of Biological Sciences, KI for the BioCentury, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Korea. ^[2] Molecular Neurogenetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.;Department of Neurology, Harvard Medical School, Boston, MA 02114, USA. ^[3] Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA. ^[4] CHDI Management/CHDI Foundation, Princeton, NJ 08540, USA. ^[5]

医学主题词人类(Humans);环AMP依赖性蛋白激酶类(Cyclic AMP-Dependent Protein Kinases);热温度(Hot Temperature);杭廷顿病(Huntington Disease);磷酰化(Phosphorylation);蛋白质组学(Proteomics)

DOI 10.1093/hmg/ddac165

PMID 35908190

发布时间 2023-02-06

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