Cysteinyl Maresins Reprogram Macrophages to Protect Mice from Streptococcus pneumoniae after Influenza A Virus Infection.

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作者： Luciana,P Tavares ^[1] ; Thayse R,Brüggemann ^[2] ; Rafael,M Rezende ^[1] ; Marina,G Machado ^[3] ; R Elaine,Cagnina ^[2] ; Ashley E,Shay ^[1] ; Cristiana,C Garcia ^[4] ; Julie,Nijmeh ^[5] ; Mauro,M Teixeira ^[1] ; Bruce D,Levy ^[2]

作者单位： Pulmonary and Critical Care Medicine Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. ^[1] Laboratório de Imunofarmacologia, Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Geraisgrid.8430.f, Belo Horizonte, Minas Gerais, Brazil. ^[2] Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. ^[3] Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. ^[4] Laboratório de Vírus Respiratórios e do Sarampo, Instituto Oswaldo Cruz (Fiocruz), Rio de Janeiro, Rio de Janeiro, Brazil. ^[5]

关键词 Streptococcus pneumoniae alveolar macrophages influenza A virus maresin conjugates in tissue regeneration (MCTRs)proresolving mediators resolution of inflammation secondary infection