Structure of the human galanin receptor 2 bound to galanin and Gq reveals the basis of ligand specificity and how binding affects the G-protein interface.

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作者： Yunseok,Heo ^[1] ; Naito,Ishimoto ^[2] ; Ye-Eun,Jeon ^[3] ; Ji-Hye,Yun ^[1] ; Mio,Ohki ^[1] ; Yuki,Anraku ^[4] ; Mina,Sasaki ^[3] ; Shunsuke,Kita ^[5] ; Hideo,Fukuhara ^[5] ; Tatsuya,Ikuta ^[5] ; Kouki,Kawakami ^[5] ; Asuka,Inoue ^[6] ; Katsumi,Maenaka ^[6] ; Jeremy R H,Tame ^[6] ; Weontae,Lee ^[5] ; Sam-Yong,Park ^[3]

作者单位： Structural Biochemistry & Molecular Biophysics Laboratory, Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, Korea. ^[1] Research Center for Bioconvergence Analysis, Korea Basic Science Institute (KBSI), Chungbuk, Korea. ^[2] Drug Design Laboratory, Graduate School of Medical Life Science, Yokohama City University, Tsurumi, Yokohama, Japan. ^[3] PCG-Biotech, Ltd., Seoul, Korea. ^[4] Faculty of Pharmaceutical Sciences and Global Station for Biosurfaces and Drug Discovery, Hokkaido University, Hokkaido, Japan. ^[5] Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan. ^[6]

主题词冷冻电子显微镜检查(Cryoelectron Microscopy);加兰肽(Galanin);异源三聚体GTP结合蛋白质类(Heterotrimeric GTP-Binding Proteins);人类(Humans);配体(Ligands);受体, 促生长激素神经肽, 2型(Receptor, Galanin, Type 2)

DOI 10.1371/journal.pbio.3001714

PMID 35913979

发布时间 2022-08-18

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