换一批Large-scale genome-wide association study of coronary artery disease in genetically diverse populations.
第一作者：
Catherine,Tcheandjieu
第一单位：
VA Palo Alto Health Care System, Palo Alto, CA, USA. catherine.tcheandjieu@gladstone.ucsf.edu.;Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA. catherine.tcheandjieu@gladstone.ucsf.edu.;Gladstone Institute of Data Science and Biotechnology, Gladstone Institutes, San Francisco, CA, USA. catherine.tcheandjieu@gladstone.ucsf.edu.;Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA. catherine.tcheandjieu@gladstone.ucsf.edu.
作者：
Catherine,Tcheandjieu [1]
;
Xiang,Zhu [2]
;
Austin T,Hilliard [3]
;
Shoa L,Clarke [4]
;
Valerio,Napolioni [5]
;
Shining,Ma [6]
;
Kyung Min,Lee [7]
;
Huaying,Fang [8]
;
Fei,Chen [9]
;
Yingchang,Lu [10]
;
Noah L,Tsao [11]
;
Sridharan,Raghavan [12]
;
Satoshi,Koyama [13]
;
Bryan R,Gorman [14]
;
Marijana,Vujkovic [15]
;
Derek,Klarin [16]
;
Michael G,Levin [15]
;
Nasa,Sinnott-Armstrong [17]
;
Genevieve L,Wojcik [18]
;
Mary E,Plomondon [19]
;
Thomas M,Maddox [20]
;
Stephen W,Waldo [21]
;
Alexander G,Bick [22]
;
Saiju,Pyarajan [23]
;
Jie,Huang [24]
;
Rebecca,Song [25]
;
Yuk-Lam,Ho [25]
;
Steven,Buyske [26]
;
Charles,Kooperberg [27]
;
Jeffrey,Haessler [27]
;
Ruth J F,Loos [28]
;
Ron,Do [29]
;
Marie,Verbanck [30]
;
Kumardeep,Chaudhary [29]
;
Kari E,North [31]
;
Christy L,Avery [31]
;
Mariaelisa,Graff [31]
;
Christopher A,Haiman [9]
;
Loïc,Le Marchand [32]
;
Lynne R,Wilkens [32]
;
Joshua C,Bis [33]
;
Hampton,Leonard [34]
;
Botong,Shen [35]
;
Leslie A,Lange [36]
;
Ayush,Giri [37]
;
Ozan,Dikilitas [38]
;
Iftikhar J,Kullo [38]
;
Ian B,Stanaway [39]
;
Gail P,Jarvik [40]
;
Adam S,Gordon [41]
;
Scott,Hebbring [42]
;
Bahram,Namjou [43]
;
Kenneth M,Kaufman [44]
;
Kaoru,Ito [13]
;
Kazuyoshi,Ishigaki [45]
;
Yoichiro,Kamatani [46]
;
Shefali S,Verma [47]
;
Marylyn D,Ritchie [47]
;
Rachel L,Kember [48]
;
Aris,Baras [49]
;
Luca A,Lotta [49]
;
Regeneron Genetics Center [50]
;
CARDIoGRAMplusC4D Consortium [51]
;
Biobank Japan [52]
;
Million Veteran Program [53]
;
Sekar,Kathiresan [54]
;
Elizabeth R,Hauser [55]
;
Donald R,Miller [23]
;
Jennifer S,Lee [23]
;
Danish,Saleheen [56]
;
Peter D,Reaven [25]
;
Kelly,Cho [57]
;
J Michael,Gaziano [58]
;
Pradeep,Natarajan [15]
;
Jennifer E,Huffman [59]
;
Benjamin F,Voight [60]
;
Daniel J,Rader [61]
;
Kyong-Mi,Chang [8]
;
Julie A,Lynch [62]
;
Scott M,Damrauer [63]
;
Peter W F,Wilson [23]
;
Hua,Tang [64]
;
Yan V,Sun ;
Philip S,Tsao ;
Christopher J,O'Donnell ;
Themistocles L,Assimes
作者单位：
VA Palo Alto Health Care System, Palo Alto, CA, USA. catherine.tcheandjieu@gladstone.ucsf.edu.;Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA. catherine.tcheandjieu@gladstone.ucsf.edu.;Gladstone Institute of Data Science and Biotechnology, Gladstone Institutes, San Francisco, CA, USA. catherine.tcheandjieu@gladstone.ucsf.edu.;Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA. catherine.tcheandjieu@gladstone.ucsf.edu.
[1]
VA Palo Alto Health Care System, Palo Alto, CA, USA.;Department of Statistics, Stanford University, Stanford, CA, USA.;Department of Statistics, The Pennsylvania State University, University Park, PA, USA.;Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, USA.
[2]
VA Palo Alto Health Care System, Palo Alto, CA, USA.
[3]
VA Palo Alto Health Care System, Palo Alto, CA, USA.;Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.
[4]
School of Biosciences and Veterinary Medicine, University of Camerino, Camerino, Italy.;Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
[5]
Department of Statistics, Stanford University, Stanford, CA, USA.
[6]
VA Informatics and Computing Infrastructure, VA Salt Lake City Health Care System, Salt Lake City, UT, USA.
[7]
Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
[8]
Department of Preventive Medicine, Center for Genetic Epidemiology, University of Southern California, Los Angeles, CA, USA.
[9]
Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA.
[10]
Department of Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
[11]
Medicine Service, VA Eastern Colorado Health Care System, Aurora, CO, USA.;Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
[12]
Laboratory for Cardiovascular Genomics and Informatics, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, Japan.
[13]
VA Boston Healthcare System, Boston, MA, USA.;Booz Allen Hamilton, McLean, VA, USA.
[14]
Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.;Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
[15]
VA Palo Alto Health Care System, Palo Alto, CA, USA.;VA Boston Healthcare System, Boston, MA, USA.;Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.;Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.;Division of Vascular Surgery and Endovascular Therapy, University of Florida School of Medicine, Gainesville, FL, USA.;Stanford University School of Medicine, Stanford, CA, USA.
[16]
VA Palo Alto Health Care System, Palo Alto, CA, USA.;Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
[17]
Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
[18]
Department of Medicine, Rocky Mountain Regional VA Medical Center, Aurora, CO, USA.;CART Program, VHA Office of Quality and Patient Safety, Washington, DC, USA.
[19]
Healthcare Innovation Lab, JC HealthCare/Washington University School of Medicine, St Louis, MO, USA.;Division of Cardiology, Washington University School of Medicine, St Louis, MO, USA.
[20]
Department of Medicine, Rocky Mountain Regional VA Medical Center, Aurora, CO, USA.;CART Program, VHA Office of Quality and Patient Safety, Washington, DC, USA.;Division of Cardiology, University of Colorado School of Medicine, Aurora, CO, USA.
[21]
Department of Biomedical Informatics, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
[22]
VA Boston Healthcare System, Boston, MA, USA.;Department of Medicine, Brigham Women's Hospital, Harvard Medical School, Boston, MA, USA.
[23]
VA Boston Healthcare System, Boston, MA, USA.;Department of Global Health, Peking University School of Public Health, Beijing, China.;School of Public Health and Emergency Management, Southern University of Science and Technology, Shenzhen, China.
[24]
VA Boston Healthcare System, Boston, MA, USA.
[25]
Department of Statistics, Rutgers University, Piscataway, NJ, USA.
[26]
Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA.
[27]
Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
[28]
Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.;Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
[29]
Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.;Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.;EA 7537 BioSTM, Université de Paris, Paris, France.
[30]
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.
[31]
Cancer Epidemiology Program, University of Hawaii Cancer Center, University of Hawaii, Honolulu, HI, USA.
[32]
Department of Medicine, Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.
[33]
Molecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA.;Data Tecnica Int'l, LLC, Glen Echo, MD, USA.
[34]
Health Disparities Research Section, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
[35]
Department of Medicine, Division of Biomedical Informatics and Personalized Medicine, Aurora, CO, USA.;Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, Aurora, CO, USA.;Department of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
[36]
Department of Medicine, Division of Epidemiology, Vanderbilt University Medical Center, Nashville, TN, USA.;Department of Obstetrics and Gynecology, Division of Quantitative Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
[37]
Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.
[38]
Department of Medicine, Division of Nephrology, University of Washington, Seattle, WA, USA.
[39]
Department of Medicine, Medical Genetics, University of Washington School of Medicine, Seattle, WA, USA.;Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.
[40]
Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
[41]
Center for Precision Medicine Research, Marshfield Clinic Research Institute, Marshfield, WI, USA.
[42]
Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.;Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
[43]
Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
[44]
Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, Japan.
[45]
Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, Japan.;Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences - The University of Tokyo, Tokyo, Japan.
[46]
Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.;Institute for Biomedical Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
[47]
Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.;Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
[48]
Regeneron Genetics Center, Tarrytown, NY, USA.
[49]
Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.;Department of Medicine, Harvard Medical School, Boston, MA, USA.;Department of Medicine, Cardiology Division, Massachusetts General Hospital, Boston, MA, USA.;Verve Therapeutics, Cambridge, MA, USA.
[50]
Cooperative Studies Program Epidemiology Center-Durham, Durham VA Health Care System, Durham, NC, USA.;Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NC, USA.
[51]
Center for Healthcare Organization and Implementation Research, Bedford VA Healthcare System, Bedford, MA, USA.;Center for Population Health, Department of Biomedical and Nutritional Sciences, University of Massachusetts, Lowell, MA, USA.
[52]
VA Palo Alto Health Care System, Palo Alto, CA, USA.;Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
[53]
Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.;Department of Medicine, Division of Cardiology, Columbia University, New York, NY, USA.
[54]
Phoenix VA Health Care System, Phoenix, AZ, USA.;College of Medicine, University of Arizona, Phoenix, AZ, USA.
[55]
Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.;Department of Medicine, Cardiology Division, Massachusetts General Hospital, Boston, MA, USA.;Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.
[56]
Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.;Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.;Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.;Institute of Translational Medicine and Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
[57]
Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
[58]
VA Salt Lake City Health Care System, Salt Lake City, UT, USA.;College of Nursing and Health Sciences, University of Massachusetts, Boston, MA, USA.
[59]
Department of Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.;Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.;Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
[60]
Atlanta VA Medical Center, Atlanta, GA, USA.;Division of Cardiology, Emory University School of Medicine, Atlanta, GA, USA.
[61]
Atlanta VA Health Care System, Atlanta, GA, USA.;Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA.
[62]
VA Palo Alto Health Care System, Palo Alto, CA, USA.;Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.;Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA.
[63]
VA Palo Alto Health Care System, Palo Alto, CA, USA. tassimes@stanford.edu.;Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA. tassimes@stanford.edu.;Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA. tassimes@stanford.edu.;Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, CA, USA. tassimes@stanford.edu.
[64]
医学主题词
冠状动脉疾病(Coronary Artery Disease);疾病遗传易感性(Genetic Predisposition to Disease);全基因组关联研究(Genome-Wide Association Study);人类(Humans);多态性, 单核苷酸(Polymorphism, Single Nucleotide);危险因素(Risk Factors)
DOI
10.1038/s41591-022-01891-3
PMID
35915156
发布时间
2026-03-06
- 浏览2
Nature medicine
Nature medicine
1679-1692页
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