LCZ696 (sacubitril/valsartan) protects against cyclophosphamide-induced nephrotoxicity in adult male rats: Up-regulation of Apelin-13/ACE2, miR-200, and down-regulation of TGF-β/SMAD 2/3 and miR-192.

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作者： Samah S,Abbas ^[1] ; Mona F,Schaalan ^[2] ; Sahar M,Gebril ^[3] ; Fatma E,Hassan ^[4] ; Maha O,Mahmoud ^[5] ; Soha O,Hassanin ^[6]

作者单位： Pharmacology and Toxicology Department, Faculty of Pharmacy, Misr International University (MIU), Cairo, Egypt. Electronic address: samah.saeed@miuegypt.edu.eg. ^[1] Pharmacy Practice and Clinical Pharmacy Department, Faculty of Pharmacy, Misr International University (MIU), Cairo, Egypt. Electronic address: mona.schaalan@miuegypt.edu.eg. ^[2] Histology Department, Faculty of Medicine, Sohag University, Sohag, Egypt. Electronic address: Sahermohamed@med.sohag.edu.eg. ^[3] Medical Physiology Department, Kasr Alainy, Faculty of Medicine, Cairo University, Cairo, Egypt; Department of Physiology, Medicine Program, Batterjee Medical College, Jeddah 21442, Saudi Arabia. Electronic address: fatma.e.elsayed@kasralainy.edu.eg. ^[4] Biochemistry Department, Faculty of Pharmacy, Egyptian Russian University, Cairo, Egypt. Electronic address: Dr_mahamahmoud@hotmail.com. ^[5] Biochemistry Department, Faculty of Pharmacy, Modern University for Technology and Information (MTI), Cairo, Egypt. Electronic address: Soha.hassanin@pharm.mti.edu.eg. ^[6]

关键词 ACE-2 Apelin-13 Cyclophosphamide LCZ696 Nephrotoxicity miR-200/192