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A SOX2-engineered epigenetic silencer factor represses the glioblastoma genetic program and restrains tumor development.

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第一作者： Valerio,Benedetti

第一单位： Stem Cell and Neurogenesis Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.

作者： Valerio,Benedetti ^[1] ; Federica,Banfi ^[2] ; Mattia,Zaghi ^[1] ; Raquel,Moll-Diaz ^[1] ; Luca,Massimino ^[1] ; Laura,Argelich ^[1] ; Edoardo,Bellini ^[1] ; Simone,Bido ^[1] ; Sharon,Muggeo ^[1] ; Gabriele,Ordazzo ^[1] ; Giuseppina,Mastrototaro ^[1] ; Matteo,Moneta ^[1] ; Alessandro,Sessa ^[1] ; Vania,Broccoli ^[2]

作者单位： Stem Cell and Neurogenesis Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy. ^[1] Stem Cell and Neurogenesis Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.;CNR Institute of Neuroscience, 20129 Milan, Italy. ^[2]

医学主题词动物(Animals);脑肿瘤(Brain Neoplasms);细胞系, 肿瘤(Cell Line, Tumor);后成说, 遗传(Epigenesis, Genetic);胶质母细胞瘤(Glioblastoma);神经胶质瘤(Glioma);人类(Humans);小鼠(Mice);肿瘤干细胞(Neoplastic Stem Cells);SOXB1转录因子类(SOXB1 Transcription Factors)

DOI 10.1126/sciadv.abn3986

PMID 35921410

发布时间 2022-08-19

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A SOX2-engineered epigenetic silencer factor represses the glioblastoma genetic program and restrains tumor development.

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A SOX2-engineered epigenetic silencer factor represses the glioblastoma genetic program and restrains tumor development.

Science advances

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