AP-1 transcription factor network explains diverse patterns of cellular plasticity in melanoma cells.

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第一作者： Natacha,Comandante-Lou

第一单位： Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908, USA; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.

作者： Natacha,Comandante-Lou ^[1] ; Douglas G,Baumann ^[2] ; Mohammad,Fallahi-Sichani ^[3]

作者单位： Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908, USA; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA. ^[1] Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908, USA. ^[2] Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908, USA; UVA Cancer Center, University of Virginia, Charlottesville, VA 22908, USA. Electronic address: fallahi@virginia.edu. ^[3]

关键词 AP-1 transcription factors BRAF-mutant melanoma CP: Cancer CP: Molecular biology MAPK signaling pathway adaptive drug resistance cellular plasticity computational modeling differentiation state heterogeneity single-cell analysis statistical learning targeted therapies

主题词细胞系, 肿瘤(Cell Line, Tumor);基因表达调控(Gene Expression Regulation);人类(Humans);黑色素瘤(Melanoma);蛋白激酶抑制剂(Protein Kinase Inhibitors);转录因子AP-1(Transcription Factor AP-1)

DOI 10.1016/j.celrep.2022.111147

PMID 35926467

发布时间 2022-09-28

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