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Rare genetic variants explain missing heritability in smoking.

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作者: Seon-Kyeong,Jang [1] ; Luke,Evans [2] ; Allison,Fialkowski [1] ; Donna K,Arnett [3] ; Allison E,Ashley-Koch [4] ; Kathleen C,Barnes [5] ; Diane M,Becker [6] ; Joshua C,Bis [7] ; John,Blangero [8] ; Eugene R,Bleecker [9] ; Meher Preethi,Boorgula [5] ; Donald W,Bowden [10] ; Jennifer A,Brody [7] ; Brian E,Cade [11] ; Brenda W Campbell,Jenkins [12] ; April P,Carson [13] ; Sameer,Chavan [5] ; L Adrienne,Cupples [14] ; Brian,Custer [15] ; Scott M,Damrauer [16] ; Sean P,David [17] ; Mariza,de Andrade [18] ; Carla L,Dinardo [19] ; Tasha E,Fingerlin [20] ; Myriam,Fornage [21] ; Barry I,Freedman [22] ; Melanie E,Garrett [4] ; Sina A,Gharib [23] ; David C,Glahn [24] ; Jeffrey,Haessler [25] ; Susan R,Heckbert [26] ; John E,Hokanson [27] ; Lifang,Hou [28] ; Shih-Jen,Hwang [29] ; Matthew C,Hyman [30] ; Renae,Judy [31] ; Anne E,Justice [32] ; Robert C,Kaplan [33] ; Sharon L R,Kardia [34] ; Shannon,Kelly [35] ; Wonji,Kim [36] ; Charles,Kooperberg [25] ; Daniel,Levy [37] ; Donald M,Lloyd-Jones [28] ; Ruth J F,Loos [38] ; Ani W,Manichaikul [39] ; Mark T,Gladwin [40] ; Lisa Warsinger,Martin [41] ; Mehdi,Nouraie [40] ; Olle,Melander [42] ; Deborah A,Meyers [9] ; Courtney G,Montgomery [43] ; Kari E,North [44] ; Elizabeth C,Oelsner [45] ; Nicholette D,Palmer [10] ; Marinelle,Payton [46] ; Anna L,Peljto [47] ; Patricia A,Peyser [34] ; Michael,Preuss [38] ; Bruce M,Psaty [48] ; Dandi,Qiao [36] ; Daniel J,Rader [49] ; Nicholas,Rafaels [5] ; Susan,Redline [11] ; Robert M,Reed [50] ; Alexander P,Reiner [25] ; Stephen S,Rich [39] ; Jerome I,Rotter [51] ; David A,Schwartz [52] ; Aladdin H,Shadyab [53] ; Edwin K,Silverman [36] ; Nicholas L,Smith [26] ; J Gustav,Smith [54] ; Albert V,Smith [55] ; Jennifer A,Smith [34] ; Weihong,Tang [56] ; Kent D,Taylor [51] ; Marilyn J,Telen [4] ; Ramachandran S,Vasan [57] ; Victor R,Gordeuk [58] ; Zhe,Wang [38] ; Kerri L,Wiggins [7] ; Lisa R,Yanek [6] ; Ivana V,Yang [47] ; Kendra A,Young [27] ; Kristin L,Young [44] ; Yingze,Zhang [40] ; Dajiang J,Liu [59] ; Matthew C,Keller [60] ; Scott,Vrieze [61]
作者单位: Department of Psychology, University of Minnesota, Minneapolis, MN, USA. [1] Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA.;Department of Ecology & Evolution, University of Colorado Boulder, Boulder, CO, USA. [2] Dean's Office, University of Kentucky College of Public Health, Lexington, KY, USA. [3] Department of Medicine, Duke University School of Medicine, Durham, NC, USA. [4] Division of Biomedical Informatics & Personalized Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. [5] Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA. [6] Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA. [7] Department of Human Genetics, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA. [8] Department of Medicine, University of Arizona, Tucson, AZ, USA. [9] Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA. [10] Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. [11] Jackson Heart Study Graduate Training and Education Center, Jackson State University School of Public Health, Jackson, MS, USA. [12] Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA. [13] Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA. [14] Vitalant Research Institute, San Francisco, CA, USA. [15] Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.;Department of Surgery, Corporal Michael Crescenz VA Medical Center, Philadelphia, PA, USA. [16] Department of Family Medicine, Prtizker School of Medicine, University of Chicago, Chicago, IL, USA.;NorthShore University HealthSystem, Evanston, IL, USA. [17] Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA. [18] Fundação Pro Sangue, São Paulo, Brazil. [19] Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.;Center for Genes Environment and Health, National Jewish Health, Denver, CO, USA. [20] Brown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA. [21] Section on Nephrology, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA. [22] Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.;Center for Lung Biology, Division of Pulmonary, Critical Care and Sleep Medicine, University of Washington, Seattle, WA, USA. [23] Department of Psychiatry, Boston Children's Hosptial and Harvard Medical School, Boston, MA, USA. [24] Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. [25] Department of Epidemiology, University of Washington, Seattle, WA, USA.;Kaiser Permanente Washington Health Research Institute, Kaiser Permanente Washington, Seattle, WA, USA. [26] Department of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. [27] Department of Preventive Medicine, Northwestern University, Chicago, IL, USA. [28] Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA. [29] Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. [30] Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. [31] Department of Population Health Sciences, Geisinger Health System, Danville, PA, USA. [32] Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.;Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA. [33] Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA. [34] Department of Pediatrics, UCSF Benioff Children's Hospital Oakland, Oakland, CA, USA. [35] Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. [36] Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.;Framingham Heart Study, Framingham, MA, USA. [37] Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.;Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. [38] Center for Public Health Genomics, School of Medicine, University of Virginia, Charlottesville, VA, USA. [39] Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. [40] Division of Cardiology, School of Medicine and Health Sciences, Washington, DC, USA. [41] Department of Clinical Sciences, Lund University, Malmö, Sweden.;Department of Internal Medicine, Skåne University Hospital, Malmö, Sweden. [42] Genes and Human Disease Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA. [43] Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. [44] Division of General Medicine, Columbia University Irving Medical Center, Columbia University, New York, NY, USA. [45] Department of Epidemiology and Biostatistics, Jackson Heart Study Graduate Training and Education Center, Jackson State University School of Public Health, Jackson, MS, USA. [46] Department of Medicine, University of Colorado School of Medicine, Aurora, CO, USA. [47] Cardiovascular Health Research Unit, Department of Medicine, Epidemiology and Health Services, University of Washington, Seattle, WA, USA. [48] Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.;Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. [49] University of Maryland School of Medicine, Baltimore, MD, USA. [50] Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA. [51] Department of Medicine, School of Medicine, University of Colorado Denver, Aurora, CO, USA.;Department of Immunology, School of Medicine, University of Colorado Denver, Aurora, CO, USA. [52] Herbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, La Jolla, CA, USA. [53] Wallenberg Laboratory/Department of Molecular and Clinical Medicine, Institute of Medicine, Gothenburg University, Gothenburg, Sweden.;Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden. [54] Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, USA. [55] Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA. [56] Sections of Preventive Medicine and Epidemiology and Cardiovascular Medicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA.;Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA. [57] Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA. [58] Department of Public Health Sciences, Penn State College of Medicine, Hershey, PA, USA. [59] Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA. [60] Department of Psychology, University of Minnesota, Minneapolis, MN, USA. vrieze@umn.edu. [61]
DOI 10.1038/s41562-022-01408-5
PMID 35927319
发布时间 2024-09-06
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Nature human behaviour

Nature human behaviour

2022年6卷11期

1577-1586页

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