Discovery of Orally Bioavailable and Brain-Penetrable Prodrugs of the Potent nSMase2 Inhibitor DPTIP.

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第一作者： Arindom,Pal

第一单位： Department of Neurology, Johns Hopkins School of Medicine, Baltimore Maryland 21205, United States.

作者： Arindom,Pal ^[1] ; Sadakatali,Gori ^[2] ; Seung-Wan,Yoo ^[1] ; Ajit G,Thomas ^[2] ; Ying,Wu ^[1] ; Jacob,Friedman ^[2] ; Lukáš,Tenora ^[2] ; Harshit,Bhasin ^[2] ; Jesse,Alt ^[1] ; Norman,Haughey ^[2] ; Barbara S,Slusher ^[1] ; Rana,Rais ^[2]

作者单位： Department of Neurology, Johns Hopkins School of Medicine, Baltimore Maryland 21205, United States. ^[1] Johns Hopkins Drug Discovery, Johns Hopkins School of Medicine, Baltimore Maryland 21205, United States. ^[2] Departments of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore Maryland 21205, United States. ^[3] Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore Maryland 21205, United States. ^[4] Department of Oncology, Johns Hopkins School of Medicine, Baltimore Maryland 21205, United States. ^[5] Departments of Neuroscience, Johns Hopkins School of Medicine, Baltimore Maryland 21205, United States. ^[6] Department of Medicine, Johns Hopkins School of Medicine, Baltimore Maryland 21205, United States. ^[7]