GNE-064: A Potent, Selective, and Orally Bioavailable Chemical Probe for the Bromodomains of SMARCA2 and SMARCA4 and the Fifth Bromodomain of PBRM1.

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作者： Alexander M,Taylor ^[1] ; Chris,Bailey ^[1] ; Lisa D,Belmont ^[2] ; Robert,Campbell ^[1] ; Nico,Cantone ^[1] ; Alexandre,Côté ^[1] ; Terry D,Crawford ^[2] ; Richard,Cummings ^[1] ; Kevin,DeMent ^[2] ; Martin,Duplessis ^[1] ; Megan,Flynn ^[2] ; Andrew C,Good ^[1] ; Hon-Ren,Huang ^[1] ; Shivangi,Joshi ^[1] ; Yves,Leblanc ^[1] ; Jeremy,Murray ^[2] ; Christopher G,Nasveschuk ^[1] ; Adrianne,Neiss ^[1] ; Florence,Poy ^[1] ; F Anthony,Romero ^[2] ; Peter,Sandy ^[1] ; Yong,Tang ^[1] ; Vickie,Tsui ^[2] ; Laura,Zawadzke ^[1] ; Robert J,Sims ^[1] ; James E,Audia ^[1] ; Steven F,Bellon ^[1] ; Steven R,Magnuson ^[2] ; Brian K,Albrecht ^[1] ; Andrea G,Cochran ^[2]

作者单位： Constellation, a Morphosys Company, 215 First Street, Suite 200, Cambridge, Massachusetts 02142, United States. ^[1] Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States. ^[2]

主题词 DNA解旋酶类(DNA Helicases);DNA结合蛋白质类(DNA-Binding Proteins);人类(Humans);核蛋白质类(Nuclear Proteins);转录因子(Transcription Factors)

DOI 10.1021/acs.jmedchem.2c00662

PMID 35930799

发布时间 2022-09-22

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