A novel therapeutic combination of dapagliflozin, Lactobacillus and crocin attenuates diabetic cardiomyopathy in rats: Role of oxidative stress, gut microbiota, and PPARγ activation.

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第一作者： Eman M,Khalaf

第一单位： Department of Microbiology and Immunology, Faculty of Pharmacy, Damanhour University, Damanhour, 22511, Egypt. Electronic address: eimanpharmacist@gmail.com.

作者： Eman M,Khalaf ^[1] ; Hanan M,Hassan ^[2] ; Ahmed M,El-Baz ^[3] ; Ahmed,Shata ^[4] ; Ahmed E,Khodir ^[5] ; Mahmoud E,Yousef ^[6] ; Rehab Mohamed,Elgharabawy ^[7] ; Nehal A,Nouh ^[8] ; Safaa,Saleh ^[9] ; Mashael M,Bin-Meferij ^[10] ; Attalla F,El-Kott ^[11] ; Mohamed M A,El-Sokkary ^[12] ; Hanan,Eissa ^[4]

作者单位： Department of Microbiology and Immunology, Faculty of Pharmacy, Damanhour University, Damanhour, 22511, Egypt. Electronic address: eimanpharmacist@gmail.com. ^[1] Biochemistry Department, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa, 11152, Egypt. ^[2] Microbiology and Biotechnology Department, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa, 11152, Egypt. ^[3] Clinical Pharmacology Department, Faculty of Medicine, Mansoura University, Mansoura, 35516, Egypt; Clinical Pharmacy Department, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa, 11152, Egypt. ^[4] Pharmacology Department, Faculty of Pharmacy, Horus University-Egypt, New Damietta, 34518, Egypt. ^[5] Pharmacology Department, Faculty of pharmacy, Delta University for Science and Technology, Gamasa, 11152, Egypt. ^[6] Pharmacology and Toxicology Department, Faculty of Pharmacy, Tanta University, Tanta, Egypt. ^[7] Department of Microbiology, Program Medicine, Batterjee Medical College, Jeddah, 6231, Saudi Arabia; Inpatient Pharmacy, Mansoura University Hospital, Mansoura, 35516, Egypt. ^[8] Department of Clinical Physiology, Faculty of Medicine, Menoufia University, Menoufia, Egypt. ^[9] Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh, 11671, Saudi Arabia; Histopathology Unit, Research Department, Health Sciences Research Center (HSRC), Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia. ^[10] Biology Department, College of Science, King Khalid University, Abha, Saudi Arabia; Zoology Department, College of Science, Damanhour University, Damanhour, Egypt. ^[11] Microbiology Department, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt. ^[12]

关键词 Cardiomyopathy Crocin Dapagliflozin Diabetes Gut microbiota Lactobacillus