Possible mechanism for improving the endogenous immune system through the blockade of peripheral μ-opioid receptors by treatment with naldemedine.

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作者： Eizoh,Gondoh ^[1] ; Yusuke,Hamada ^[2] ; Tomohisa,Mori ^[2] ; Yusuke,Iwazawa ^[3] ; Asami,Shinohara ^[2] ; Michiko,Narita ^[2] ; Daisuke,Sato ^[2] ; Hiroyuki,Tezuka ^[3] ; Takayasu,Yamauchi ^[4] ; Mayu,Tsujimura ^[2] ; Sara,Yoshida ^[3] ; Kenichi,Tanaka ^[5] ; Kensuke,Yamashita ^[6] ; Haruka,Akatori ^[2] ; Kimio,Higashiyama ^[2] ; Kazuhiko,Arakawa ^[3] ; Yukari,Suda ^[2] ; Kanako,Miyano ^[3] ; Masako,Iseki ^[2] ; Eiichi,Inada ^[6] ; Naoko,Kuzumaki ^[6] ; Minoru,Narita ^[2]

作者单位： Department of Anesthesiology and Pain Medicine, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan. ^[1] Department of Pharmacology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2-4-41 Ebara, Shinagawa-ku, Tokyo, 142-8501, Japan. ^[2] Division of Cancer Pathophysiology, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan. ^[3] Department of Molecular and Cellular Medicine, Institute of Medical Science, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan. ^[4] Department of Cellular Function Analysis, Research Promotion Headquarters, Fujita Health University, Aichi, Japan. ^[5] Institute of Medicinal Chemistry, Hoshi University, 2-4-41, Ebara, Shinagawa-ku, Tokyo, 142-8501, Japan. ^[6] Department of Anesthesiology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan. ^[7] Department of Pharmacology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2-4-41 Ebara, Shinagawa-ku, Tokyo, 142-8501, Japan. n-kuzumaki@hoshi.ac.jp. ^[8] Division of Cancer Pathophysiology, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan. n-kuzumaki@hoshi.ac.jp. ^[9] Department of Anesthesiology and Pain Medicine, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan. narita@hoshi.ac.jp. ^[10] Department of Pharmacology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2-4-41 Ebara, Shinagawa-ku, Tokyo, 142-8501, Japan. narita@hoshi.ac.jp. ^[11] Division of Cancer Pathophysiology, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan. narita@hoshi.ac.jp. ^[12]