Neuroinflammation inhibition by small-molecule targeting USP7 noncatalytic domain for neurodegenerative disease therapy.

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作者： Xiao-Wen,Zhang ^[1] ; Na,Feng ^[1] ; Yan-Chen,Liu ^[1] ; Qiang,Guo ^[1] ; Jing-Kang,Wang ^[1] ; Yi-Zhen,Bai ^[1] ; Xiao-Ming,Ye ^[1] ; Zhuo,Yang ^[1] ; Heng,Yang ^[1] ; Yang,Liu ^[1] ; Mi-Mi,Yang ^[2] ; Yan-Hang,Wang ^[1] ; Xiao-Meng,Shi ^[1] ; Dan,Liu ^[3] ; Peng-Fei,Tu ^[1] ; Ke-Wu,Zeng ^[1]

作者单位： State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China. ^[1] Department of Toxicology, School of Public Health, Peking University, Beijing 100191, China. ^[2] Proteomics Laboratory, Medical and Healthy Analytical Center, Peking University Health Science Center, Beijing 100191, China. ^[3]

主题词动物(Animals);小鼠(Mice);NF-E2相关因子2(NF-E2-Related Factor 2);神经变性疾病(Neurodegenerative Diseases);小分子化合物库(Small Molecule Libraries);泛素硫酯酶(Ubiquitin Thiolesterase)

DOI 10.1126/sciadv.abo0789

PMID 35947662

发布时间 2023-03-31

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Science advances

2022年8卷32期

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Neuroinflammation inhibition by small-molecule targeting USP7 noncatalytic domain for neurodegenerative disease therapy.

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Neuroinflammation inhibition by small-molecule targeting USP7 noncatalytic domain for neurodegenerative disease therapy.

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