Roxadustat alleviates nitroglycerin-induced migraine in mice by regulating HIF-1α/NF-κB/inflammation pathway.

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作者： Dai-Gang,Yang ^[1] ; Yong-Yao,Gao ^[1] ; Ze-Qun,Yin ^[1] ; Xue-Rui,Wang ^[1] ; Xian-She,Meng ^[1] ; Ting-Feng,Zou ^[1] ; Ya-Jun,Duan ^[1] ; Yuan-Li,Chen ^[1] ; Chen-Zhong,Liao ^[1] ; Zhou-Ling,Xie ^[1] ; Xiao-Dong,Fan ^[2] ; Lu,Sun ^[2] ; Ji-Hong,Han ^[3] ; Xiao-Xiao,Yang ^[4]

作者单位： Key Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes, College of Food and Biological Engineering, Hefei University of Technology, Hefei, 230009, China. ^[1] Department of General Gynecology, Tianjin Central Hospital of Gynecology and Obstetrics/Tianjin Key Laboratory of Human Development and Reproductive Regulation, Tianjin, 300100, China. ^[2] Key Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes, College of Food and Biological Engineering, Hefei University of Technology, Hefei, 230009, China. jihonghan2008@nankai.edu.cn. ^[3] College of Life Sciences, Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials of Ministry of Education, Nankai University, Tianjin, 300071, China. jihonghan2008@nankai.edu.cn. ^[4] Key Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes, College of Food and Biological Engineering, Hefei University of Technology, Hefei, 230009, China. yangxiaoxiao@hfut.edu.cn. ^[5]

关键词 HIF-1α ROS central sensitization migraine neuroinflammation roxadustat