A conformational switch controlling the toxicity of the prion protein.

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第一作者： Karl,Frontzek

第一单位： Institute of Neuropathology, University of Zurich, Zurich, Switzerland.

作者： Karl,Frontzek ^[1] ; Marco,Bardelli ^[2] ; Assunta,Senatore ^[3] ; Anna,Henzi ^[1] ; Regina R,Reimann ^[1] ; Seden,Bedir ^[1] ; Marika,Marino ^[1] ; Rohanah,Hussain ^[4] ; Simon,Jurt ^[5] ; Georg,Meisl ^[6] ; Mattia,Pedotti ^[7] ; Federica,Mazzola ^[2] ; Giuliano,Siligardi ^[2] ; Oliver,Zerbe ^[5] ; Marco,Losa ^[6] ; Tuomas,Knowles ^[1] ; Asvin,Lakkaraju ^[7] ; Caihong,Zhu ^[1] ; Petra,Schwarz ^[1] ; Simone,Hornemann ^[1] ; Matthew G,Holt ^[1] ; Luca,Simonelli ^[4] ; Luca,Varani ^[8] ; Adriano,Aguzzi ^[2]

作者单位： Institute of Neuropathology, University of Zurich, Zurich, Switzerland. ^[1] Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland. ^[2] PetMedix Ltd, Babraham Research Campus, Cambridge, UK. ^[3] Laboratory of Glia Biology, VIB-KU Leuven Center for Brain and Disease Research, Leuven, Belgium. ^[4] B23 Beamline, Diamond Light Source, Harwell Science Innovation Campus, Didcot, UK. ^[5] University of Zurich, Department of Chemistry, Zurich, Switzerland. ^[6] Department of Chemistry, University of Cambridge, Cambridge, UK. ^[7] Laboratory of Synapse Biology, Instituto de Investigação e Inovação em Saúde (i3S), University of Porto, Porto, Portugal. ^[8] Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland. luca.varani@irb.usi.ch. ^[9] Institute of Neuropathology, University of Zurich, Zurich, Switzerland. adriano.aguzzi@usz.ch. ^[10]