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Role of Keap1-Nrf2/ARE signal transduction pathway in protection of dexmedetomidine preconditioning against myocardial ischemia/reperfusion injury.

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第一作者： Hui-Xian,Li

第一单位： Department of Anesthesiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

作者： Hui-Xian,Li ^[1] ; Tai-Hang,Wang ^[1] ; Lin-Xin,Wu ^[1] ; Fu-Shan,Xue ^[2] ; Guo-Hua,Zhang ^[3] ; Tao,Yan ^[1]

作者单位： Department of Anesthesiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China. ^[1] Department of Anesthesiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China. ^[2] Department of Anesthesiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.;Department of Anesthesiology, National Cancer Center/National Clinical Research Center for Cancer/Hebei Cancer Hospital, Chinese Academy of Medical Sciences, Langfang 065001, China. ^[3]

关键词 Dexmedetomidine Keap1-Nrf2/ARE signal transduction pathway Myocardial ischemia/reperfusion injury Oxidative stress