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Pembrolizumab, radiotherapy, and an immunomodulatory five-drug cocktail in pretreated patients with persistent, recurrent, or metastatic cervical or endometrial carcinoma: Results of the phase II PRIMMO study.

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第一作者: Emiel A,De Jaeghere
第一单位: Department of Medical Oncology (Route 535), Ghent University Hospital, C. Heymanslaan 10, 9000, Ghent, Belgium.;Cancer Research Institute Ghent (CRIG), Ghent, Belgium.;Laboratory of Experimental Cancer Research, Department of Human Structure and Repair, Ghent University, Ghent, Belgium.
作者单位: Department of Medical Oncology (Route 535), Ghent University Hospital, C. Heymanslaan 10, 9000, Ghent, Belgium.;Cancer Research Institute Ghent (CRIG), Ghent, Belgium.;Laboratory of Experimental Cancer Research, Department of Human Structure and Repair, Ghent University, Ghent, Belgium. [1] Gynaecologic Oncology, Department of Oncology, KU Leuven, Leuven, Belgium.;Leuven Cancer Institute, Leuven, Belgium.;Department of Medical Oncology, University Hospital Brussels, Brussels, Belgium.;Laboratory for Medical and Molecular Oncology (LMMO), VUB, Brussels, Belgium. [2] Anticancer Fund (ACF), Strombeek-Bever, Belgium. [3] Biostatistics and Statistical Bioinformatics Centre (L-BioStat), KU Leuven, Leuven, Belgium. [4] Gynaecologic Oncology, Department of Oncology, KU Leuven, Leuven, Belgium.;Leuven Cancer Institute, Leuven, Belgium. [5] Cancer Research Institute Ghent (CRIG), Ghent, Belgium.;Laboratory of Experimental Cancer Research, Department of Human Structure and Repair, Ghent University, Ghent, Belgium. [6] Department of Hemato-Oncology, Centre Hospitalier Universitaire Université Catholique de Louvain Namur (Sainte-Elisabeth), Namur, Belgium. [7] Department of Gynecologic Oncology and Senology, University Hospital Antwerp, Edegem, Belgium.;Multidisciplinary Oncologic Centre Antwerp (MOCA), University Hospital Antwerp, Edegem, Belgium.;Center for Oncological Research (CORE), Integrated Personalized and Precision Oncology Network (IPPON), Edegem, Belgium. [8] Department of Medical Oncology, University Hospital Brussels, Brussels, Belgium. [9] Department of Radiation Oncology, Jules Bordet Institute, Brussels, Belgium.;Department of Radiation Oncology, General Hospital Sint-Maarten, Mechlin, Belgium. [10] Department of Medical Oncology (Route 535), Ghent University Hospital, C. Heymanslaan 10, 9000, Ghent, Belgium.;Cancer Research Institute Ghent (CRIG), Ghent, Belgium. [11] VIB-KU Leuven Center for Cancer Biology, Leuven, Belgium. [12] Cancer Research Institute Ghent (CRIG), Ghent, Belgium.;Department of Pathology, Ghent University Hospital, Ghent, Belgium.;Center for Gynecologic Oncology Amsterdam (CGOA), Netherlands Cancer Institute and Amsterdam Medical Center, Amsterdam, The Netherlands. [13] Gynaecologic Oncology, Department of Oncology, KU Leuven, Leuven, Belgium.;Center for Gynecologic Oncology Amsterdam (CGOA), Netherlands Cancer Institute and Amsterdam Medical Center, Amsterdam, The Netherlands.;Department of Gynecology and Obstetrics, University Hospitals Leuven, Leuven, Belgium. [14] Cancer Research Institute Ghent (CRIG), Ghent, Belgium.;Department of Radiation Oncology, Ghent University Hospital, Ghent, Belgium. [15] Department of Medical Oncology (Route 535), Ghent University Hospital, C. Heymanslaan 10, 9000, Ghent, Belgium. hannelore.denys@ugent.be.;Cancer Research Institute Ghent (CRIG), Ghent, Belgium. hannelore.denys@ugent.be. [16]
DOI 10.1007/s00262-022-03253-x
PMID 35960332
发布时间 2025-01-04
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Cancer immunology, immunotherapy : CII

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