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Functional inactivation of Plasmodium falciparum glycogen synthase kinase GSK3 modulates erythrocyte invasion and blocks gametocyte maturation.

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第一作者： Arne,Alder

第一单位： CSSB Centre for Structural Systems Biology, Hamburg, Germany; Department of Cellular Parasitology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany; Department of Biology, University of Hamburg, Hamburg, Germany.

作者： Arne,Alder ^[1] ; Louisa,Wilcke ^[1] ; Emma,Pietsch ^[1] ; Heidrun,von Thien ^[1] ; Samuel,Pazicky ^[2] ; Christian,Löw ^[2] ; Paolo,Mesen-Ramirez ^[1] ; Anna,Bachmann ^[1] ; Paul-Christian,Burda ^[1] ; Conrad,Kunick ^[3] ; Holger,Sondermann ^[4] ; Danny,Wilson ^[5] ; Tim-Wolf,Gilberger ^[6]

作者单位： CSSB Centre for Structural Systems Biology, Hamburg, Germany; Department of Cellular Parasitology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany; Department of Biology, University of Hamburg, Hamburg, Germany. ^[1] CSSB Centre for Structural Systems Biology, Hamburg, Germany; Hamburg Unit, European Molecular Biology Laboratory, Hamburg, Germany. ^[2] Institut für Medizinische und Pharmazeutische Chemie, Technische Universität Braunschweig, Braunschweig, Germany. ^[3] CSSB Centre for Structural Systems Biology, Hamburg, Germany; Deutsches Elektronen-Synchrotron DESY, Germany; Christian-Albrechts-Universität zu Kiel, Kiel, Germany. ^[4] CSSB Centre for Structural Systems Biology, Hamburg, Germany; Department of Cellular Parasitology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany; Research Centre for Infectious Diseases, School of Biological Sciences, University of Adelaide, South Australia, Australia; Burnet Institute, Melbourne, Victoria, Australia; Institute for Photonics and Advanced Sensing (IPAS), University of Adelaide, South Australia, Australia. ^[5] CSSB Centre for Structural Systems Biology, Hamburg, Germany; Department of Cellular Parasitology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany; Department of Biology, University of Hamburg, Hamburg, Germany. Electronic address: gilberger@bnitm.de. ^[6]

关键词 GSK3 Plasmodium falciparum gametocytogenesis host cell invasion kinase malaria