New C-6 functionalized quinoline NorA inhibitors strongly synergize with ciprofloxacin against planktonic and biofilm growing resistant Staphylococcus aureus strains.

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作者： Tommaso,Felicetti ^[1] ; Nicholas,Cedraro ^[2] ; Andrea,Astolfi ^[1] ; Giada,Cernicchi ^[1] ; Gianmarco,Mangiaterra ^[3] ; Salvatore,Vaiasicca ^[4] ; Serena,Massari ^[1] ; Giuseppe,Manfroni ^[1] ; Maria Letizia,Barreca ^[1] ; Oriana,Tabarrini ^[1] ; Francesca,Biavasco ^[2] ; Violetta,Cecchetti ^[1] ; Carla,Vignaroli ^[5] ; Stefano,Sabatini ^[6]

作者单位： Department of Pharmaceutical Sciences, Università degli Studi di Perugia, via del Liceo 1, 06123, Perugia, Italy. ^[1] Department of Life and Environmental Science, Università Politecnica delle Marche, via Brecce Bianche, 60131, Ancona, Italy. ^[2] Department of Life and Environmental Science, Università Politecnica delle Marche, via Brecce Bianche, 60131, Ancona, Italy; Department of Biomolecular Sciences, Division of Pharmacology and Hygiene, University of Urbino, Via S. Chiara 27, 61029, Urbino, Italy. ^[3] Department of Molecular and Clinical Sciences, Università Politecnica delle Marche, Via Tronto 10/a, 60020, Ancona, Italy. ^[4] Department of Life and Environmental Science, Università Politecnica delle Marche, via Brecce Bianche, 60131, Ancona, Italy. Electronic address: c.vignaroli@univpm.it. ^[5] Department of Pharmaceutical Sciences, Università degli Studi di Perugia, via del Liceo 1, 06123, Perugia, Italy. Electronic address: stefano.sabatini@unipg.it. ^[6]

关键词 Antibiotic resistance breakers Antimicrobial resistance Biofilm Efflux pump inhibitors NorA Staphylococcus aureus